Recombinant Rat RANTES (CCL5) 0 ReviewsSubmit a Review Product Details Catalog Number: 400-13 Description: RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Rat RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta AA Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Determined by its ability to chemoattract rat peritoneal macrophages using a concentration range of 50.0-100.0 ng/ml. Assay #2: Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 7.9 kDa Accession Number: P50231 Gene ID: 81780 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Human + Rat, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Transplantation Recent Citations First Author Abu-Taha, M Title Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. Citation Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1393-402 PubMed ID 19553526 First Author Abu Nabah, Y N Title CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration. Citation Arteriosclerosis, Thrombosis, and Vascular Biology; 27(11) pg2370-6 PubMed ID 17717298 First Author Mateo, T Title A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles. Citation Blood; 110(6) pg1895-902 PubMed ID 17595330
