PeproGMP

As cell therapies transition from the lab to patients’ bedsides, ensuring the highest levels of quality and safety is a significant and critical challenge. PeproTech’s PeproGMP® Cytokines help researchers meet that challenge. Consistent with federal requirements and best practices for cell therapy, gene therapy, and tissue-engineered products for clinical applications, PeproGMP® Cytokines are manufactured and tested in compliance with US FDA GMP (Good Manufacturing Practices) regulations and the ISO 9001 quality management systems standard, without the use of animal-derived materials.

PeproGMP® Cytokines offer safety, purity, and simplified use in ex vivo manufacturing processes, as described in USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.'

Size

775.00 USD 50µg
1,450.00 USD 100µg
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PeproGMP® Recombinant Human IL-3

SKU: GMP200-03

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages.  Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity.  Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles.  Many of the IL-3 activities depend upon co-stimulation with other cytokines.  IL-3 is a species-specific, variably glycosylated cytokine.

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

Size

290.00 USD 10µg
1,450.00 USD 100µg
Looking for a custom size?
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PeproGMP® Recombinant Human IL-6

SKU: GMP200-06

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions.

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

New

Size

450.00 USD 100µg
1,000.00 USD 500µg
Looking for a custom size?
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PeproGMP® Recombinant Human EGF

SKU: GMP100-15

EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells.  Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing.  EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor.  This receptor also binds with TGF-α and VGF (vaccinia virus growth factor).

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

New

Size

240.00 USD 25µg
720.00 USD 100µg
3,600.00 USD 1mg
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PeproGMP® Recombinant Human FGF-basic

SKU: GMP100-18B

FGF-basic (154 a.a.) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.


Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

Size

870.00 USD 50µg
1,450.00 USD 100µg
Looking for a custom size?
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PeproGMP® Recombinant Human Flt3-Ligand

SKU: GMP300-19

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells.  Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3.  Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation.  Unlike SCF, Flt3-Ligand exerts no activity on mast cells.  Multiple isoforms of Flt3-Ligand have been identified.  The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.).  The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform.

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: MTQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

Size

775.00 USD 50µg
1,450.00 USD 100µg
Looking for a custom size?
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PeproGMP® Recombinant Human SCF

SKU: GMP300-07

SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor.

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.

New

Size

1,050.00 USD 50µg
1,750.00 USD 100µg
Looking for a custom size?
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PeproGMP® Recombinant Human TPO

SKU: GMP300-18

TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. 

Additional product information and specifications are provided on the Certificate of Analysis.

AA Sequence: SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Source: E.coli

Note: Please contact Customer Service for a quote on our PeproGMP® products.