Pre-Coated ELISA Kits

Biogems

Human BMP-2 Pre-Coated ELISA Kit

제품 상세

카다로그 번호 BGK8C060
제품 설명

BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. The BioGems Human BMP-2 Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure BMP-2 with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for BMP-2. It contains CHO-expressed recombinant BMP-2. The detection antibody is a biotinylated goat polyclonal antibody specific for BMP-2. The kit is analytically validated with ready to use reagents.

Sandwich ELISA:

Assay Type:
Solid Phase Sandwich ELISA: 96-Well Strip Plate
Sensitivity:
<2 pg/ml 
Range:
31.2pg/ml-2000pg/ml
Specificity:
Natural and recombinant Human BMP-2
Uniprot:
  C8C060
Interference:
No detectable cross-reactivity with other relevant proteins

Note:

Product supplied by Biogems

Country Of Origin: USA

Not for human use.