A 83-01 제품 상세 카다로그 번호 9094360 제품 설명 A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal. Synonyms: A-83-01, A83-01, ALK5 Inhibitor IV, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083 Application: Formulation: Crystalline solid Chemical Name: 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide Molecular Formula: C25H19N5S Molecular Weight: 421.5 CAS Number: 909910-43-6 Purity: ≥95% Note: Product supplied by Biogems Product Line Country Of Origin: USA Not for human use.
