Animal-Free Recombinant Human CNTF 0 ReviewsSubmit a Review Product Details Catalog Number: AF-450-13 Description: CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Ciliary Neurotrophic Factor AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml. Calculated Molecular Weight: 22.8 kDa Accession Number: P26441 Gene ID: 1270 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Monkey References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Yun, Y Title CRISPR-mediated Gene Correction Links the ATP7A M1311V Mutations With Amyotrophic Lateral Sclerosis Pathogenesis in One Individual Citation Communications Biology; 3(1) pg33 PubMed ID 31959876 First Author Peng, Y Title Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina. Citation Cell; 176(5) pg1222-1237.e22 PubMed ID 30712875
