Recombinant Murine Adiponectin 0 ReviewsSubmit a Review Product Details Catalog Number: 315-26 Description: Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant Murine Adiponectin is a multimeric glycoprotein, which has a calculated molecular weight of 25.8 kDa and contains amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. As a result of glycosylation, Recombinant Murine Adiponectin migrates with an apparent molecular mass of approximately 31-36 kDa by SDS-PAGE gel, under reducing conditions. Source: Hi-5 Insect cells Synonyms: Acrp-30, GBP-28, APM-1 AA Sequence: RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 4.0-6.0 μg/ml. Calculated Molecular Weight: 25.8 kDa Accession Number: Q60994 Gene ID: 11450 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation Immune System Inflammation Neurobiology Recent Citations First Author Takenaga, K Title Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice. Citation Scientific Reports; 11(1) pg2923 PubMed ID 33536560 First Author Grases-Pintó, B Title Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation. Citation Scientific Reports; 9(1) pg1786 PubMed ID 30742004 First Author Liu, Z Title Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Citation Cell death & disease; 7(11) pge2487 PubMed ID 27882945