Recombinant Murine Amphiregulin 0 ReviewsSubmit a Review Product Details Catalog Number: 315-36 Description: Amphiregulin is an EGF-related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Murine Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues. Source: E.coli Synonyms: AR, AREG, Colorectum cell-derived growth factor (CRDGF) AA Sequence: SVRVEQVIKP KKNKTEGEKS TEKPKRKKKG GKNGKGRRNK KKKNPCTAKF QNFCIHGECR YIENLEVVTC NCHQDYFGER CGEKSMKTHS EDDKDLSK Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 11.5 kDa Accession Number: P31955 Gene ID: 11839 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Cell Culture Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Lindzen, M Title Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53 Citation Oncogene; 40(21) pg3665-3679 PubMed ID 33941851 First Author Pasciuto, E Title Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Citation Cell; 182(3) pg625-640.e24 PubMed ID 32702313
