Recombinant Murine APRIL 0 评论Submit a Review 产品详情 产品编号: 315-13 产品描述: APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues. Source: E.coli Synonyms: A Proliferating-inducing Ligand, TNFSF13, TRDL-1, TALL-2, CD256 AA Sequence: MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce cell proliferation of activated T cells. Calculated Molecular Weight: 21.9 kDa Accession Number: Q9D777 Gene ID: 69583 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞凋亡 癌症 免疫系统 TNF超家族 product.subtitle.recentcitations 第一作者 Wigton, E J 标题 MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination. 文献引用 The Journal of Experimental Medicine; 218(11) PubMed Id 34586363 第一作者 Liu, L 标题 Circulating CD138 enhances disease progression by augmenting autoreactive antibody production in a mouse model of systemic lupus erythematosus. 文献引用 The Journal of Biological Chemistry; 297(3) pg101053 PubMed Id 34364875 第一作者 Sang, A 标题 Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. 文献引用 Nature Communications; 9(1) pg3973 PubMed Id 30266981