Recombinant Murine C10 (CCL6) 0 ReviewsSubmit a Review Product Details Catalog Number: 250-06 Description: Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant Murine C10 is a 10.7 kDa protein containing 95 amino acid residues. Source: E.coli Synonyms: CCL6, MRP-1 AA Sequence: GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract Balb/c mouse spleen MNCs using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 10.7 kDa Accession Number: P27784 Gene ID: 20305 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Wound Healing Recent Citations First Author Krishnan, V Title Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1 Citation Communications Biology; 3(1) pg524 PubMed ID 32963283 First Author Demircioglu, F Title Cancer associated fibroblast FAK regulates malignant cell metabolism. Citation Nature Communications; 11(1) pg1290 PubMed ID 32157087 First Author Yagawa, Y Title Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy. Citation Scientific Reports; 7(1) pg15996 PubMed ID 29167448
