Human CD40 Ligand Pre-Coated ELISA Kit 제품 상세 카다로그 번호 BGK29965 제품 설명 CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anCHOred CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to ""immunodeficiency with hyper-IgM"", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The BioGems Human CD40 Ligand Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure CD40 Ligand with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for CD40 Ligand. It contains E.coli-expressed recombinant CD40 Ligand. The detection antibody is a biotinylated goat polyclonal antibody specific for CD40 Ligand. The kit is analytically validated with ready to use reagents. Sandwich ELISA: Assay Type: Solid Phase Sandwich ELISA: 96-Well Strip Plate Sensitivity: <15 pg/ml Range: 62.5pg/ml-4000pg/ml Specificity: Natural and recombinant Human CD40 Ligand Uniprot: P29965 Interference: No detectable cross-reactivity with other relevant proteins Note: Product supplied by Biogems Product Line Country Of Origin: USA Not for human use.