Recombinant Human 4-1BB Ligand

제품 상세

카다로그 번호 310-11

제품 설명

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

Source: E.coli

Synonyms: TNFSF9, CD137L

AA Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED₅₀ for this effect is 5-10 ng/ml.
Please Note: Results may vary with PBMC donors.

Calculated Molecular Weight: 19.5 kDa

Accession Number: P41273

Gene ID: 8744

crossreactivity:

Human

Research Interest