Recombinant Human BAFF

Recombinant Human BAFF

제품 상세

카다로그 번호 310-13

제품 설명

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFFR. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZNTF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED₅₀ for this effect is 0.5-2.0 µg/ml.

Calculated Molecular Weight: 17 kDa

Accession Number: Q9Y275

Gene ID: 10673

Cross Reactivity:

Human , Mouse, N/A

Research Interest

Stem Cells & Differentiation

TNF Superfamily

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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15 Mar 2004

14630796
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Moreaux, J

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.

Blood; 103(8) pg3148-57

15 Apr 2004

15070697
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Bischof, D

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15 Apr 2006

16357320
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1 Apr 2007

17119122
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Blood; 111(3) pg1644-53

1 Feb 2008

18025152
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Fu, L

BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells.

Blood; 113(19) pg4627-36

7 May 2009

19258594
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Guo, F

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

Blood; 114(14) pg2909-16

1 Oct 2009

19671922
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Blood; 114(21) pg4675-86

19 Nov 2009

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21 Jan 2010

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17 Feb 2011

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Enzler, T

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Hamzaoui, K

BAFF is up-regulated in central nervous system of neuro-BehÃ§et's disease.

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30 Aug 2008

18625522
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Debnath, I

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Wu, J

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Claudio, E

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Vallabhapurapu, S

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So, L

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Tusche, M W

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23 Nov 2009

19917778
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22 Nov 2010

21041452
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Jacque, E

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

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1 Jun 2015

25987726
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Yang, M

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1 Sep 2005

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Ohmae, T

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1 Dec 2005

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Perchonock, C E

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1 Aug 2007

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Watanabe, M

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15 Apr 2008

18390703
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Claudio, E

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.

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1 Feb 2009

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Claudio, E

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Haas, K M

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15 Sep 2009

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King, R G

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1 Oct 2011

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Kreuzaler, M

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Journal of immunology (Baltimore, Md. : 1950); 188(1) pg497-503

1 Jan 2012

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Volpi, S A

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1 Dec 2012

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Ma, N

BAFF suppresses IL-15 expression in B cells.

Journal of immunology (Baltimore, Md. : 1950); 192(9) pg4192-201

1 May 2014

24670802
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1 Dec 2014

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15 Oct 2015

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15 Nov 2013

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Zhang, W

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2 Nov 2010

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2 Oct 2012

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