Recombinant Human BAFF

Recombinant Human BAFF

제품 상세

카다로그 번호 310-13

제품 설명

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZNTF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED₅₀ for this effect is 0.5-2.0 µg/ml.

Cross Reactivity:

Human, Mouse, N/A

Research Interest

Stem Cells & Differentiation

TNF Superfamily

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

Yang, M

B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells

The Journal of Immunology; 175(5):2814-24

1 Sep 2005

16116167
Show Usages

Bretz, J

Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors.

Blood; 117(7):2179-88

17 Feb 2011

21163929
Show Usages

Tangye, S G

BAFF, APRIL and human B cell disorders.

Seminars in Immunology; 18(5):305-17.

1 Oct 2006

16916610
Show Usages

Tusche, M W

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.

The Journal of Experimental Medicine; 206(12):2671-83.

23 Nov 2009

19917778
Show Usages

Good, K L

Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells.

The Journal of Immunology; 182(2):890-901.

15 Jan 2009

19124732
Show Usages

Claudio, E

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.

The Journal of Immunology; 182(3):1617-30.

1 Feb 2009

19155511
Show Usages

Daridon, C

Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome.

Arthritis and Rheumatism; 54(7):2280-8.

1 Jul 2006

16802367
Show Usages

Claudio, E

Cell-autonomous role for NF-kappaB in immature bone marrow B cells.

The Journal of Immunology; 182(6):3406-13.

15 Mar 2009

19265118
Show Usages

Fu, L

BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells.

Blood; 113(19):4627-36

7 May 2009

19258594
Show Usages

Haas, K M

CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.

The Journal of Immunology; 183(6):3661-71.

15 Sep 2009

19710450
Show Usages

Herling, M

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.

Blood; 114:4675-4686

21 Sep 2009

19770358
Show Usages

Suryani, S

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

Blood; 115(3):519-29.

21 Jan 2010

19965666
Show Usages

Kis, L L

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood; 117(1):165-74.

6 Jan 2011

20876453
Show Usages

Pham, L V

Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-kappaB-inducing kinase while activating both canonical and alternative nuclear factor-kappaB pathways.

Blood; 117(1):200-10

6 Jan 2011

20889926
Show Usages

Zhang, W

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.

Proceedings of the National Academy of Sciences of the USA; 107(44):18956-60.

2 Nov 2010

20956327
Show Usages

Hildebrand, J M

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.

The Journal of Experimental Medicine; 207(12):2569-79.

22 Nov 2010

21041452
Show Usages

Conze, D B

Non-canonical NF-B activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

PLoS Biology; 8(10):e1000518.

26 Oct 2010

21048983
Show Usages

Zhang, S

RhoA of the Rho family small GTPases is essential for B lymphocyte development.

PLoS ONE; 7(3):e33773

16 Mar 2012

22438996
Show Usages

King, R G

Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response.

The Journal of Immunology; 187(7):3565-77

1 Oct 2011

21873522
Show Usages

Volpi, S A

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

The Journal of Immunology; 188(6):2556-66

15 Mar 2012

22345664
Show Usages

Kreuzaler, M

Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.

Journal of Immunology; 188(1):497-503

1 Jan 2012

22124120
Show Usages

Enoksson, S L

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

Proceedings of the National Academy of Sciences of the USA; 108(51):E1399-407

20 Dec 2011

22135456
Show Usages

Saada, S

Differential Expression of Neurotensin and Specific Receptors, NTSR1 and NTSR2, in Normal and Malignant Human B Lymphocytes.

The Journal of Immunology; 189(11):5293-303

1 Dec 2012

23109725
Show Usages

Benson, M J

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.

Proceedings of the National Academy of Sciences of the USA; 109(40):16252-7.

2 Oct 2012

22991471
Show Usages

Mahévas, M

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.

The Journal of Clinical Investigation; 123(1):432-42

2 Jan 2013

23241960
Show Usages

So, L

Selective Inhibition of Phosphoinositide 3-Kinase p110α Preserves Lymphocyte Function.

The Journal of Biological Chemistry; 288(8):5718-31

22 Feb 2013

23275335
Show Usages

Huang, H W

B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.

Proceedings of the National Academy of Sciences of the USA; 110(27):10928-33

2 Jul 2013

23776238
Show Usages

Rodríguez-Bayona, B

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

The Journal of Immunology; 191(10):4996-5004

15 Nov 2013

24101550
Show Usages

Ma, N

BAFF suppresses IL-15 expression in B cells.

The Journal of Immunology; 192(9):4192-201

1 May 2014

24670802
Show Usages

Hartweger, H

Themis2 is not required for B cell development, activation, and antibody responses.

The Journal of Immunology; 193(2):700-7

15 Jul 2014

24907343
Show Usages

Soni, C

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.

The Journal of Immunology; 193(9):4400-14

1 Nov 2014

25252960
Show Usages

Ramos-Amaya, A

Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.

The Journal of Immunology; 194(3):1031-8

1 Feb 2015

25548228
Show Usages

Reis, C R

Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors

Molecular & Cellular Proteomics; 10(1):M110.002808

0 Jan 2011

20852190
Show Usages

Kong, S

DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.

The Journal of Immunology; 193(11):5515-24

1 Dec 2014

25362179
Show Usages

Keppler, S J

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

Immunity; 43(4):660-73

20 Oct 2015

26453379
Show Usages

Kong, S

Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation.

The Journal of Immunology; 195(8):3685-93

15 Oct 2015

26378077
Show Usages

Jacque, E

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

The Journal of Experimental Medicine; 212(6):883-92

1 Jun 2015

25987726
Show Usages

Su, K Y

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

The Journal of Immunology; 197(10):4163-4176

15 Nov 2016

27815447
Show Usages

Dijkstra, D

Human Basophils Modulate Plasma Cell Differentiation and Maturation.

The Journal of Immunology; 198(1):229-238

1 Jan 2017

27852746
Show Usages

Zhivaki , D

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.

Immunity;

21 Feb 2017

28228284
Show Usages

Wu , J L

O-GlcNAcylation is required for B cell homeostasis and antibody responses.

Nature Communications;

30 Nov 2017

29187734
Show Usages

McCarthy , K R

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

Immunity;

16 Jan 2018

29343437
Show Usages

Guo , F

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

Blood; 114(14):2909-16

1 Oct 2009

19671922
Show Usages