Recombinant Human BAFF

Recombinant Human BAFF

제품 상세

카다로그 번호 310-13

제품 설명

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFFR. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZNTF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED₅₀ for this effect is 0.5-2.0 µg/ml.

Cross Reactivity:

Human , Mouse, N/A

Research Interest

Stem Cells & Differentiation

TNF Superfamily

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

Claudio, E

BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

Nature Immunology; 3(10) pg958-65

0 Oct 2002

12352969
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Hase, H

BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.

Blood; 103(6) pg2257-65

15 Mar 2004

14630796
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Moreaux, J

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.

Blood; 103(8) pg3148-57

15 Apr 2004

15070697
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Yang, M

B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.

Journal of immunology (Baltimore, Md. : 1950); 175(5) pg2814-24

1 Sep 2005

16116167
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Ohmae, T

Helicobacter pylori activates NF-kappaB via the alternative pathway in B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 175(11) pg7162-9

1 Dec 2005

16301619
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Bischof, D

Selective activation of TACI by syndecan-2.

Blood; 107(8) pg3235-42

15 Apr 2006

16357320
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Aiba, Y

BANK negatively regulates Akt activation and subsequent B cell responses.

Immunity; 24(3) pg259-68

0 Mar 2006

16546095
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Daridon, C

Identification of transitional type II B cells in the salivary glands of patients with SjÃ¶gren's syndrome.

Arthritis and Rheumatism; 54(7) pg2280-8

0 Jul 2006

16802367
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Tangye, S G

BAFF, APRIL and human B cell disorders.

Seminars in Immunology; 18(5) pg305-17

0 Oct 2006

16916610
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Enzler, T

Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.

Immunity; 25(3) pg403-15

0 Sep 2006

16973390
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Sakurai, D

TACI regulates IgA production by APRIL in collaboration with HSPG.

Blood; 109(7) pg2961-7

1 Apr 2007

17119122
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Debnath, I

Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23.

Molecular Immunology; 44(9) pg2388-99

0 Mar 2007

17140663
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Perchonock, C E

The related adaptors, adaptor in lymphocytes of unknown function X and Rlk/Itk-binding protein, have nonredundant functions in lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 179(3) pg1768-75

1 Aug 2007

17641043
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Kim, S

Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.

Blood; 111(3) pg1644-53

1 Feb 2008

18025152
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Watanabe, M

Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.

Journal of immunology (Baltimore, Md. : 1950); 180(8) pg5222-34

15 Apr 2008

18390703
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Hamzaoui, K

BAFF is up-regulated in central nervous system of neuro-BehÃ§et's disease.

Journal of Neuroimmunology; 200(1-2) pg111-4

30 Aug 2008

18625522
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Vallabhapurapu, S

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.

Nature Immunology; 9(12) pg1364-70

0 Dec 2008

18997792
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Good, K L

Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells.

Journal of immunology (Baltimore, Md. : 1950); 182(2) pg890-901

15 Jan 2009

19124732
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Claudio, E

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950); 182(3) pg1617-30

1 Feb 2009

19155511
Show Usages

Fu, L

BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells.

Blood; 113(19) pg4627-36

7 May 2009

19258594
Show Usages

Claudio, E

Cell-autonomous role for NF-kappa B in immature bone marrow B cells.

Journal of immunology (Baltimore, Md. : 1950); 182(6) pg3406-13

15 Mar 2009

19265118
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Guo, F

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

Blood; 114(14) pg2909-16

1 Oct 2009

19671922
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Haas, K M

CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.

Journal of immunology (Baltimore, Md. : 1950); 183(6) pg3661-71

15 Sep 2009

19710450
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Herling, M

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.

Blood; 114(21) pg4675-86

19 Nov 2009

19770358
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Tusche, M W

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.

The Journal of Experimental Medicine; 206(12) pg2671-83

23 Nov 2009

19917778
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Suryani, S

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

Blood; 115(3) pg519-29

21 Jan 2010

19965666
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Reis, C R

Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.

Molecular & cellular proteomics : MCP; 10(1) pgM110.002808

0 Jan 2011

20852190
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Kis, L L

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood; 117(1) pg165-74

6 Jan 2011

20876453
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Pham, L V

Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-ÎºB-inducing kinase while activating both canonical and alternative nuclear factor-ÎºB pathways.

Blood; 117(1) pg200-10

6 Jan 2011

20889926
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Zhang, W

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.

Proceedings of the National Academy of Sciences of the United States of America; 107(44) pg18956-60

2 Nov 2010

20956327
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Hildebrand, J M

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.

The Journal of Experimental Medicine; 207(12) pg2569-79

22 Nov 2010

21041452
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Conze, D B

Non-canonical NF-ÎºB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

PLoS Biology; 8(10) pge1000518

26 Oct 2010

21048983
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Bretz, J

Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors.

Blood; 117(7) pg2179-88

17 Feb 2011

21163929
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King, R G

Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response.

Journal of immunology (Baltimore, Md. : 1950); 187(7) pg3565-77

1 Oct 2011

21873522
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Kreuzaler, M

Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.

Journal of immunology (Baltimore, Md. : 1950); 188(1) pg497-503

1 Jan 2012

22124120
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Enoksson, S L

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

Proceedings of the National Academy of Sciences of the United States of America; 108(51) pgE1399-407

20 Dec 2011

22135456
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Volpi, S A

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Journal of immunology (Baltimore, Md. : 1950); 188(6) pg2556-66

15 Mar 2012

22345664
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Zhang, S

RhoA of the Rho family small GTPases is essential for B lymphocyte development.

PLoS ONE; 7(3) pge33773

0 2012

22438996
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Benson, M J

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.

Proceedings of the National Academy of Sciences of the United States of America; 109(40) pg16252-7

2 Oct 2012

22991471
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Saada, S

Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 189(11) pg5293-303

1 Dec 2012

23109725
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So, L

Selective inhibition of phosphoinositide 3-kinase p110Î± preserves lymphocyte function.

The Journal of Biological Chemistry; 288(8) pg5718-31

22 Feb 2013

23275335
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Huang, H

B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.

Proceedings of the National Academy of Sciences of the United States of America; 110(27) pg10928-33

2 Jul 2013

23776238
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Ma, N

BAFF suppresses IL-15 expression in B cells.

Journal of immunology (Baltimore, Md. : 1950); 192(9) pg4192-201

1 May 2014

24670802
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Hartweger, H

Themis2 is not required for B cell development, activation, and antibody responses.

Journal of immunology (Baltimore, Md. : 1950); 193(2) pg700-7

15 Jul 2014

24907343
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Soni, C

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.

Journal of immunology (Baltimore, Md. : 1950); 193(9) pg4400-14

1 Nov 2014

25252960
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Kong, S

DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-ÎºB transcriptional activity.

Journal of immunology (Baltimore, Md. : 1950); 193(11) pg5515-24

1 Dec 2014

25362179
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Ramos-Amaya, A

Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 194(3) pg1031-8

1 Feb 2015

25548228
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Jacque, E

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

The Journal of Experimental Medicine; 212(6) pg883-92

1 Jun 2015

25987726
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Kong, S

Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKÎ± Phosphorylation.

Journal of immunology (Baltimore, Md. : 1950); 195(8) pg3685-93

15 Oct 2015

26378077
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Keppler, S J

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.

Immunity; 43(4) pg660-73

20 Oct 2015

26453379
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Su, K

Efficient Culture of Human Naive and Memory B Cells for Use as APCs.

Journal of immunology (Baltimore, Md. : 1950); 197(10) pg4163-4176

15 Nov 2016

27815447
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Dijkstra, D

Human Basophils Modulate Plasma Cell Differentiation and Maturation.

Journal of immunology (Baltimore, Md. : 1950); 198(1) pg229-238

1 Jan 2017

27852746
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Zhivaki, D

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.

Immunity; 46(2) pg301-314

21 Feb 2017

28228284
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Wu, J

O-GlcNAcylation is required for B cell homeostasis and antibody responses.

Nature Communications; 8(1) pg1854

30 Nov 2017

29187734
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McCarthy, K R

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

Immunity; 48(1) pg174-184.e9

16 Jan 2018

29343437
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Mahévas, M

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.

The Journal of Clinical Investigation; 123(1) pg432-42

0 Jan 2013

23241960
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Rodríguez-Bayona, B

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950); 191(10) pg4996-5004

15 Nov 2013

24101550
Show Usages

Mahévas, M

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.

The Journal of Clinical Investigation; 123(1) pg432-42

0 Jan 2013

23241960
Show Usages

Rodríguez-Bayona, B

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950); 191(10) pg4996-5004

15 Nov 2013

24101550
Show Usages

Watanabe, A

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.

Cell; 177(5) pg1124-1135.e16

16 May 2019

31100267
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