Recombinant Human BD-1 (36 a.a.) 0 리뷰submitareview 제품 상세 카다로그 번호 300-51 제품 설명 Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues. Source: E.coli Synonyms: Beta-Defensin 1, DEFB1, HBD1 AA Sequence: DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml. Calculated Molecular Weight: 3.9 kDa Accession Number: P60022 Gene ID: 1672 crossreactivity: Bacteria, Human, Research Interest Chemotaxis Immune System Stem Cells & Differentiation References PubMed SDS Product Line Country Of Origin: USA Not for human use.