Animal-Free Recombinant Human BMP-4 (E.coli derived)

제품 상세

카다로그 번호 AF-120-05ET

제품 설명

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, and includes a N-terminal Met residue. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4

AA Sequence (monomer): MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED₅₀ for this effect is 5-10 ng/ml.

Calculated Molecular Weight: 23.9 kDa

Accession Number: P12644

Gene ID: 652

Note:

1mg will be provided as 2x500μg.

crossreactivity:

Human, Mouse, Rat, Salamander

Research Interest