Recombinant Human Eotaxin (CCL11)

Recombinant Human Eotaxin (CCL11)

제품 상세

카다로그 번호 300-21

제품 설명

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.

Cross Reactivity:

Bacteria, Guinea Pig, Human , Human + Guinea Pig, Human + Hamster, Human + Mouse, Mouse, N/A, Rat

Research Interest

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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Martinelli, R

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Konya, V

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Tiffany, H L

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Oravecz, T

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1 Dec 1997

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Bonecchi, R

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5 Jan 1998

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Górski, P

Eotaxin but not MCP-3 induces eosinophil influx into nasal fluid in allergic patients.

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Böhm, E

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The Journal of Biological Chemistry; 279(9) pg7663-70

27 Feb 2004

14668348
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Górski, P

Eotaxin but not MCP-3 induces eosinophil influx into nasal fluid in allergic patients.

Allergy; 57(6) pg519-28

0 Jun 2002

12028117
Show Usages

Böhm, E

11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

The Journal of Biological Chemistry; 279(9) pg7663-70

27 Feb 2004

14668348
Show Usages