Recombinant Human Eotaxin (CCL11)

Recombinant Human Eotaxin (CCL11)

제품 상세

카다로그 번호 300-21

제품 설명

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.

Cross Reactivity:

Bacteria, Guinea Pig, Human, Human + Guinea Pig, Human + Hamster, Leech, Mouse, N/A, Rat

Research Interest

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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15 Apr 1999

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17 Mar 2000

10713092
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The Journal of Biological Chemistry; 275(34):25985-25992.

25 Aug 2000

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Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309

The Journal of Experimental Medicine; 186(1):165-170.

7 Jul 1997

9207005
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Oravecz, T

Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cells Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

The Journal of Experimental Medicine; 186(11):1865-1872.

1 Dec 1997

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Science; 279(5349):381.

2 Apr 2000

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Clements, D

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The Journal of Immunology; 185(3):1812-21.

1 Aug 2010

20585037
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Hartnell, A

Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2

The Journal of Immunology; 173(10):6448-57

15 Nov 2004

15528386
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Ferland, C

IL-16 activates plasminogen-plasmin system and promotes human eosinophil migration into extracellular matrix via CCR3-chemokine-mediated signaling and by modulating CD4 eosinophil expression

The Journal of Immunology; 173(7):4417-24

1 Oct 2004

15383572
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Howard, O M

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Blood; 105(11):4207-14

1 Jun 2005

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Munitz, A

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.

Blood; 107(5):1996-2003

1 Mar 2006

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Ponte, A L

The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities

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1 Jul 2007

17395768
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Bryan, S A

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American Journal of Respiratory and Critical Care Medicine; 165(12):1602-9.

15 Jun 2002

12070060
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Spiegl, N

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid

Blood; 112(9):3762-71

1 Nov 2008

18495959
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Takeda, A

CCR3 is a target for age-related macular degeneration diagnosis and therapy.

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9 Jul 2009

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Izhak, L

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

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1 Jul 2009

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Yung, S C

Host Chemokines Bind to Staphylococcus aureus and Stimulate Protein A Release.

The Journal of Biological Chemistry; 286(7):5069-77.

18 Feb 2011

21138841
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Pazdrak, K

Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.

The Journal of Immunology; 186(11):6485-96.

1 Jun 2011

21525390
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Dianzani, C

B7h triggering inhibits the migration of tumor cell lines.

The Journal of Immunology; 192(10):4921-31

15 May 2014

24733850
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Lessel, D

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5

Scientific Reports; 6:33231

13 Sep 2016

27618959
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Singh, K

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

ACS Medicinal Chemistry Letters;

27 Jun 2017

28655871
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Costa , A

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.

Cancer Cell;

12 Mar 2018

29455927
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Alenazi, Y

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets

Scientific Reports;

20 Apr 2018

29679010
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Zhang, Y

A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma

Scientific Reports;

8 Nov 2017

29118379
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