Animal-Free Recombinant Human GDF-3

제품 상세

카다로그 번호 AF-120-22

제품 설명

GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia that characterizes Type 2 diabetes. Recombinant Human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Growth/Differentiation Factor-3, Vgr-2, UNQ2222/PRO248

AA Sequence (monomer): AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED₅₀ for this effect is 100-150 ng/ml.

Calculated Molecular Weight: 26 kDa

Accession Number: Q9NR23

Gene ID: 9573

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)