Recombinant Human GDNF 3 리뷰Submit a Review 제품 상세 카다로그 번호 450-10 제품 설명 GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa. Source: E.coli Synonyms: Glial-Derived Neurotrophic Factor, ATF-1 AA Sequence (monomer): MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 30.4 kDa Accession Number: P39905 Gene ID: 2668 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bird, Frog, Human, Human + Hamster, Human + Mouse, Human + Rat, Human + Virus, Monkey, Mouse, Rat References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations 제 1 저자 Pantazis, C B 주제 A reference human induced pluripotent stem cell line for large-scale collaborative studies. 인용 Cell Stem Cell; 29(12) pg1685-1702.e22 PubMed ID 36459969 제 1 저자 Kaluscha, S 주제 Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation. 인용 Nature Genetics; 54(12) pg1895-1906 PubMed ID 36471082 제 1 저자 Mesci, P 주제 SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. 인용 PLoS Biology; 20(11) pge3001845 PubMed ID 36327326 product.subtitle.productreviews 기존 리뷰 High quality product Used for human stem cells. Awesome product! 에서: Danielle | 날짜: 2020-08-26 × High quality product Used for human stem cells. Awesome product! 에서: Danielle | 날짜: 2020-08-26 Close Cortical Neuron Differentiation Very consistent for culturing human stem cells 에서: Danielle | 날짜: 2021-08-24 × Cortical Neuron Differentiation Very consistent for culturing human stem cells 에서: Danielle | 날짜: 2021-08-24 Close iPSC-derived neurons Used successfully as part of a battery of growth factors and small molecules to differentiate iPSCs into neurons. 에서: Mandi | 날짜: 2021-08-25 × iPSC-derived neurons Used successfully as part of a battery of growth factors and small molecules to differentiate iPSCs into neurons. 에서: Mandi | 날짜: 2021-08-25 Close
