Recombinant Human IL-7

제품 상세

카다로그 번호 200-07

제품 설명

IL-7 is a hematopoietic growth factor that primarily affects early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors, such as ConA and IL-2. Human and murine IL-7 are cross-species reactive. Recombinant Human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

Source: E.coli

Synonyms: Lymphopoietin 1(LP-1), pre-B cell factor

AA Sequence: MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.

Note:

1mg will be provided as 2x500μg.

Cross Reactivity:

Bacteria, Human , Human + Hamster, Human + Mouse, Human + Virus, Leech, Monkey, Mouse, Mouse + Human, N/A, Rabbit, Rat

Research Interest

Immune System

Inflammation

Stem Cells & Differentiation

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

Imai, T

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.

International Immunology; 11(1) pg81-8

0 Jan 1999

10050676
Show Usages

Takaki, A

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C.

Nature Medicine; 6(5) pg578-82

0 May 2000

10802716
Show Usages

Denizot, Y

Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells.

Cytokine; 12(5) pg499-502

0 May 2000

10857767
Show Usages

Besse, A

Effect of cytokines and growth factors on the macrophage colony-stimulating factor secretion by human bone marrow stromal cells.

Cytokine; 12(5) pg522-5

0 May 2000

10857771
Show Usages

Pandey, A

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.

Nature Immunology; 1(1) pg59-64

0 Jul 2000

10881176
Show Usages

Olosz, F

Three loops of the common gamma chain ectodomain required for the binding of interleukin-2 and interleukin-7.

The Journal of Biological Chemistry; 275(39) pg30100-5

29 Sep 2000

10887198
Show Usages

Kessler, J H

Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.

The Journal of Experimental Medicine; 193(1) pg73-88

1 Jan 2001

11136822
Show Usages

Shah, N

Clonal variation in the B-lineage acute lymphoblastic leukemia response to multiple cytokines and bone marrow stromal cells.

Cancer Research; 61(13) pg5268-74

1 Jul 2001

11431369
Show Usages

Dardalhon, V

IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America; 98(16) pg9277-82

31 Jul 2001

11470908
Show Usages

Stepkowski, S M

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.

Blood; 99(2) pg680-9

15 Jan 2002

11781254
Show Usages

Olosz, F

Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.

The Journal of Biological Chemistry; 277(14) pg12047-52

5 Apr 2002

11815609
Show Usages

Sivori, S

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation.

Proceedings of the National Academy of Sciences of the United States of America; 99(7) pg4526-31

2 Apr 2002

11917118
Show Usages

Arai, F

Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation.

The Journal of Experimental Medicine; 195(12) pg1549-63

17 Jun 2002

12070283
Show Usages

Velazquez, L

Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.

The Journal of Experimental Medicine; 195(12) pg1599-611

17 Jun 2002

12070287
Show Usages

Kinet, S

gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.

Blood; 100(7) pg2546-53

1 Oct 2002

12239168
Show Usages

Sinha, M L

Interleukin 7 worsens graft-versus-host disease.

Blood; 100(7) pg2642-9

1 Oct 2002

12239180
Show Usages

Manel, N

The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis.

Blood; 101(5) pg1913-8

1 Mar 2003

12393496
Show Usages

Warming, S

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related KrÃ¼ppel-like zinc finger protein.

Blood; 101(5) pg1934-40

1 Mar 2003

12393497
Show Usages

Ohishi, K

Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.

The Journal of Clinical Investigation; 110(8) pg1165-74

0 Oct 2002

12393852
Show Usages

Jurickova, I

Generation of alloreactive anti-leukemic cytotoxic T lymphocytes with attenuated GVHD properties from haploidentical parents in childhood acute lymphoblastic leukemia.

Bone Marrow Transplantation; 30(10) pg687-97

0 Nov 2002

12420208
Show Usages

Hildesheim, A

Simultaneous measurement of several cytokines using small volumes of biospecimens.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology; 11(11) pg1477-84

0 Nov 2002

12433730
Show Usages

Hemminki, A

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer Research; 63(4) pg847-53

15 Feb 2003

12591736
Show Usages

Schlienger, K

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research; 9(4) pg1517-27

0 Apr 2003

12684428
Show Usages

Jung, U

CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effects.

Blood; 102(9) pg3439-46

1 Nov 2003

12855580
Show Usages

Mulloy, J C

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

Blood; 102(13) pg4369-76

15 Dec 2003

12946995
Show Usages

Kunisato, A

Stem cell leukemia protein directs hematopoietic stem cell fate.

Blood; 103(9) pg3336-41

1 May 2004

14726394
Show Usages

Rooney, S

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Proceedings of the National Academy of Sciences of the United States of America; 101(8) pg2410-5

24 Feb 2004

14983023
Show Usages

Wang, B

Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein.

Blood; 104(1) pg200-6

1 Jul 2004

15016646
Show Usages

Sugita, Y

NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors.

Cancer Research; 64(6) pg2199-204

15 Mar 2004

15026363
Show Usages

Heath, V

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo.

Blood; 104(6) pg1639-47

15 Sep 2004

15073037
Show Usages

Baskar, S

Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes.

The Journal of Clinical Investigation; 113(10) pg1498-510

0 May 2004

15146248
Show Usages

Porritt, H E

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages.

Immunity; 20(6) pg735-45

0 Jun 2004

15189738
Show Usages

Lin, L

Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.

The Journal of Experimental Medicine; 200(1) pg115-22

5 Jul 2004

15226356
Show Usages

Shah, N

Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.

Blood; 104(9) pg2873-8

1 Nov 2004

15242874
Show Usages

Zhang, X

Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.

Blood; 104(10) pg3276-84

15 Nov 2004

15265789
Show Usages

Schmitt, T M

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.

The Journal of Experimental Medicine; 200(4) pg469-79

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15314075
Show Usages

Gimeno, R

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

Blood; 104(13) pg3886-93

15 Dec 2004

15319293
Show Usages

Vodyanik, M A

Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential.

Blood; 105(2) pg617-26

15 Jan 2005

15374881
Show Usages

La Motte-Mohs, R N

Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro.

Blood; 105(4) pg1431-9

15 Feb 2005

15494433
Show Usages

Medin, J A

Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo.

Cancer Gene Therapy; 12(6) pg540-51

0 Jun 2005

15678150
Show Usages

van Beek, J

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

Journal of immunology (Baltimore, Md. : 1950); 174(4) pg2353-65

15 Feb 2005

15699172
Show Usages

Mandal, M

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

The Journal of Experimental Medicine; 201(4) pg603-14

21 Feb 2005

15728238
Show Usages

Erdmann, A A

Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo.

Blood; 105(12) pg4707-14

15 Jun 2005

15746085
Show Usages

Michiels, A

Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines.

Gene Therapy; 12(9) pg772-82

0 May 2005

15750615
Show Usages

Li, Y

IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro.

Journal of immunology (Baltimore, Md. : 1950); 174(7) pg4019-24

1 Apr 2005

15778359
Show Usages

Jones, K S

Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta.

Journal of immunology (Baltimore, Md. : 1950); 174(7) pg4262-70

1 Apr 2005

15778389
Show Usages

Kaufman, H L

Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma.

The Journal of Clinical Investigation; 115(7) pg1903-12

0 Jul 2005

15937544
Show Usages

Dimitrova, D I

Lentivirus-mediated transduction of PKR into CD34(+) hematopoietic stem cells inhibits HIV-1 replication in differentiated T cell progeny.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research; 25(6) pg345-60

0 Jun 2005

15957958
Show Usages

Baratelli, F

Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950); 175(3) pg1483-90

1 Aug 2005

16034085
Show Usages

Moran, T P

A novel viral system for generating antigen-specific T cells.

Journal of immunology (Baltimore, Md. : 1950); 175(5) pg3431-8

1 Sep 2005

16116238
Show Usages

Goodyear, O

CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden.

Blood; 106(13) pg4217-24

15 Dec 2005

16144804
Show Usages

Milicic, A

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

Journal of immunology (Baltimore, Md. : 1950); 175(7) pg4618-26

1 Oct 2005

16177107
Show Usages

Gattinoni, L

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells.

The Journal of Experimental Medicine; 202(7) pg907-12

3 Oct 2005

16203864
Show Usages

Foley, J E

Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950); 175(9) pg5732-43

1 Nov 2005

16237064
Show Usages

Willinger, T

Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets.

Journal of immunology (Baltimore, Md. : 1950); 175(9) pg5895-903

1 Nov 2005

16237082
Show Usages

Dai, S

More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells.

Clinical cancer research : an official journal of the American Association for Cancer Research; 11(20) pg7554-63

15 Oct 2005

16243831
Show Usages

Johnson, S E

Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells.

Journal of immunology (Baltimore, Md. : 1950); 175(11) pg7325-31

1 Dec 2005

16301638
Show Usages

Manigold, T

Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.

Blood; 107(11) pg4424-32

1 Jun 2006

16478885
Show Usages

Michiels, A

Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.

Gene Therapy; 13(13) pg1027-36

0 Jul 2006

16511519
Show Usages

Mongkolsapaya, J

T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?

Journal of immunology (Baltimore, Md. : 1950); 176(6) pg3821-9

15 Mar 2006

16517753
Show Usages

Wunderlich, M

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

Blood; 108(5) pg1690-7

1 Sep 2006

16670269
Show Usages

Vodyanik, M A

Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures.

Blood; 108(6) pg2095-105

15 Sep 2006

16757688
Show Usages

Bauer, A

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Proceedings of the National Academy of Sciences of the United States of America; 103(29) pg10979-84

18 Jul 2006

16832056
Show Usages

Carrasco, J

CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation.

Blood; 108(9) pg2897-905

1 Nov 2006

16857986
Show Usages

Delhommeau, F

Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.

Blood; 109(1) pg71-7

1 Jan 2007

16954506
Show Usages

Vanheusden, K

In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.

Stem cells (Dayton, Ohio); 25(1) pg107-14

0 Jan 2007

16973833
Show Usages

Steele, J C

The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens.

British Journal of Cancer; 95(9) pg1202-11

6 Nov 2006

17024127
Show Usages

Ito, D

The wild-type sequence (wt) p53(25-35) peptide induces HLA-DR7 and HLA-DR11-restricted CD4+ Th cells capable of enhancing the ex vivo expansion and function of anti-wt p53(264-272) peptide CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950); 177(10) pg6795-803

15 Nov 2006

17082593
Show Usages

Sato, N

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

Proceedings of the National Academy of Sciences of the United States of America; 104(2) pg588-93

9 Jan 2007

17202253
Show Usages

Peluso, I

IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 178(2) pg732-9

15 Jan 2007

17202333
Show Usages

Zhang, Z

TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.

Blood; 109(10) pg4328-35

15 May 2007

17255353
Show Usages

Vassena, L

Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals.

Proceedings of the National Academy of Sciences of the United States of America; 104(7) pg2355-60

13 Feb 2007

17284597
Show Usages

Khan, N

T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection.

Journal of immunology (Baltimore, Md. : 1950); 178(7) pg4455-65

1 Apr 2007

17372003
Show Usages

Fluur, C

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.

Journal of immunology (Baltimore, Md. : 1950); 178(8) pg5340-50

15 Apr 2007

17404319
Show Usages

Volpe, G

Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches.

Cancer Research; 67(11) pg5300-7

1 Jun 2007

17545610
Show Usages

Raffaghello, L

Expression and functional analysis of human leukocyte antigen class I antigen-processing machinery in medulloblastoma.

Cancer Research; 67(11) pg5471-8

1 Jun 2007

17545629
Show Usages

Mitra-Kaushik, S

Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses.

Journal of immunology (Baltimore, Md. : 1950); 179(2) pg1303-12

15 Jul 2007

17617623
Show Usages

Schuster, I G

Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies.

Blood; 110(8) pg2931-9

15 Oct 2007

17626842
Show Usages

Tran, D Q

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.

Blood; 110(8) pg2983-90

15 Oct 2007

17644734
Show Usages

Abdul-Hai, A

Interleukin-7 induced facilitation of immunological reconstitution of sublethally irradiated mice following treatment with alloreactive spleen cells in a murine model of B-cell leukemia/lymphoma (BCL1).

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0 Nov 2007

17704792
Show Usages

Neviani, P

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.

The Journal of Clinical Investigation; 117(9) pg2408-21

0 Sep 2007

17717597
Show Usages

Sakuishi, K

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

Journal of immunology (Baltimore, Md. : 1950); 179(6) pg3452-62

15 Sep 2007

17785779
Show Usages

Park, J

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Nature Immunology; 8(10) pg1049-59

0 Oct 2007

17873878
Show Usages

Liu, H

The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope.

Clinical immunology (Orlando, Fla.); 125(3) pg337-45

0 Dec 2007

17900990
Show Usages

van Lent, A U

Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors.

Journal of immunology (Baltimore, Md. : 1950); 179(8) pg4959-68

15 Oct 2007

17911580
Show Usages

Racanelli, V

Bone marrow of persistently hepatitis C virus-infected individuals accumulates memory CD8+ T cells specific for current and historical viral antigens: a study in patients with benign hematological disorders.

Journal of immunology (Baltimore, Md. : 1950); 179(8) pg5387-98

15 Oct 2007

17911625
Show Usages

Jiang, X

HLA Tetramer Based Artificial Antigen-Presenting Cells Efficiently Stimulate CTLs Specific for Malignant Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research; 13(24) pg7329-34

15 Dec 2007

18094414
Show Usages

Mariotti, J

Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection.

Journal of immunology (Baltimore, Md. : 1950); 180(1) pg89-105

1 Jan 2008

18097008
Show Usages

Hou, Y

Distinct CD8+ T cell repertoires primed with agonist and native peptides derived from a tumor-associated antigen.

Journal of immunology (Baltimore, Md. : 1950); 180(3) pg1526-34

1 Feb 2008

18209048
Show Usages

Caprioli, F

Autocrine regulation of IL-21 production in human T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 180(3) pg1800-7

1 Feb 2008

18209077
Show Usages

Lee, A W

Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection.

Journal of Virology; 82(7) pg3702-12

0 Apr 2008

18216116
Show Usages

Wei, J

Dendritic cells expressing a combined PADRE/MUC4-derived polyepitope DNA vaccine induce multiple cytotoxic T-cell responses.

Cancer biotherapy & radiopharmaceuticals; 23(1) pg121-8

0 Feb 2008

18298336
Show Usages

Sartorius, R

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Journal of immunology (Baltimore, Md. : 1950); 180(6) pg3719-28

15 Mar 2008

18322177
Show Usages

Yang, Y

Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells.

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18322183
Show Usages

Chen, C I

Development and dynamics of robust T-cell responses to CML under imatinib treatment.

Blood; 111(11) pg5342-9

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18326818
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Rethi, B

Priming of T cells to Fas-mediated proliferative signals by interleukin-7.

Blood; 112(4) pg1195-204

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18441236
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Schmidlin, H

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Blood; 112(5) pg1804-12

1 Sep 2008

18552212
Show Usages

Svirshchevskaya, E V

Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity.

BMC Cancer; 8 pg176

21 Jun 2008

18570671
Show Usages

Cohen, P A

STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.

Blood; 112(5) pg1832-43

1 Sep 2008

18577706
Show Usages

Fytili, P

Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073.

Vaccine; 26(31) pg3818-26

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18582999
Show Usages

Mariotti, J

Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway.

Blood; 112(12) pg4765-75

1 Dec 2008

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Goodyear, O C

Differential pattern of CD4+ and CD8+ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma.

Blood; 112(8) pg3362-72

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ter Brake, O

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model.

Gene Therapy; 16(1) pg148-53

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Skowera, A

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

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18802479
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Su, Z

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.

Clinical cancer research : an official journal of the American Association for Cancer Research; 14(19) pg6207-17

1 Oct 2008

18829500
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Li, C K

T cell responses to whole SARS coronavirus in humans.

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18832706
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Kaneko, S

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Blood; 113(5) pg1006-15

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Carreno, B M

CD40 regulates human dendritic cell-derived IL-7 production that, in turn, contributes to CD8(+) T-cell antigen-specific expansion.

Immunology and Cell Biology; 87(2) pg167-77

0 Feb 2009

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Figueiredo, C

Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.

Blood; 113(13) pg3008-16

26 Mar 2009

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Symes, J C

Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells.

Cancer Gene Therapy; 16(5) pg439-52

0 May 2009

19096446
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Nijmeijer, B A

Long-term culture of primary human lymphoblastic leukemia cells in the absence of serum or hematopoietic growth factors.

Experimental Hematology; 37(3) pg376-85

0 Mar 2009

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Show Usages

Ahlen, M T

T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.

Blood; 113(16) pg3838-44

16 Apr 2009

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Lundberg, K

A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols.

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4 Mar 2009

19171173
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Czystowska, M

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.

Cell Death and Differentiation; 16(5) pg708-18

0 May 2009

19180118
Show Usages

Nicholls, S

Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.

Proceedings of the National Academy of Sciences of the United States of America; 106(10) pg3889-94

10 Mar 2009

19234124
Show Usages

Henry, R A

Functional silencing is initiated and maintained in immature anti-insulin B cells.

Journal of immunology (Baltimore, Md. : 1950); 182(6) pg3432-9

15 Mar 2009

19265121
Show Usages

Sakaguchi, M

Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.

The Journal of Biological Chemistry; 284(21) pg14236-44

22 May 2009

19279003
Show Usages

Sawa, Y

Hepatic interleukin-7 expression regulates T cell responses.

Immunity; 30(3) pg447-57

20 Mar 2009

19285437
Show Usages

Xue, X

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.

Blood; 114(7) pg1319-30

13 Aug 2009

19414858
Show Usages

Awong, G

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Blood; 114(5) pg972-82

30 Jul 2009

19491395
Show Usages

Rayment, R

Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers.

Journal of immunology (Baltimore, Md. : 1950); 183(1) pg677-86

1 Jul 2009

19535639
Show Usages

Eberhard, Y

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Blood; 114(14) pg3064-73

1 Oct 2009

19589922
Show Usages

Hagn, M

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950); 183(3) pg1838-45

1 Aug 2009

19592644
Show Usages

Centlivre, M

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

Gene Therapy; 17(1) pg14-25

0 Jan 2010

19727135
Show Usages

Vercoulen, Y

Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells.

PLoS ONE; 4(9) pge7183

25 Sep 2009

19779623
Show Usages

Peperzak, V

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.

The Journal of Clinical Investigation; 120(1) pg168-78

0 Jan 2010

19955658
Show Usages

Racanelli, V

Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.

Blood; 115(6) pg1185-93

11 Feb 2010

20008301
Show Usages

Liang, X

A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.

Journal of immunology (Baltimore, Md. : 1950); 184(3) pg1617-29

1 Feb 2010

20042572
Show Usages

Sivori, S

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.

Blood; 116(10) pg1637-47

9 Sep 2010

20147700
Show Usages

Henriques, C M

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

Blood; 115(16) pg3269-77

22 Apr 2010

20190194
Show Usages

Joosten, S A

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

PLoS Pathogens; 6(2) pge1000782

26 Feb 2010

20195504
Show Usages

Cella, M

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.

Proceedings of the National Academy of Sciences of the United States of America; 107(24) pg10961-6

15 Jun 2010

20534450
Show Usages

Guo, P

Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.

Blood; 116(12) pg2061-9

23 Sep 2010

20538796
Show Usages

Lee, S H

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

Journal of immunology (Baltimore, Md. : 1950); 185(2) pg917-28

15 Jul 2010

20543098
Show Usages

Martin, J F

An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.

Journal of immunology (Baltimore, Md. : 1950); 185(2) pg1311-20

15 Jul 2010

20543101
Show Usages

Yui, M A

Fine-scale staging of T cell lineage commitment in adult mouse thymus.

Journal of immunology (Baltimore, Md. : 1950); 185(1) pg284-93

1 Jul 2010

20543111
Show Usages

Birkholz, K

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation.

Blood; 116(13) pg2277-85

30 Sep 2010

20566893
Show Usages

Tripathi, P

STAT5 is critical to maintain effector CD8+ T cell responses.

Journal of immunology (Baltimore, Md. : 1950); 185(4) pg2116-24

15 Aug 2010

20644163
Show Usages

Kis, L L

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood; 117(1) pg165-74

6 Jan 2011

20876453
Show Usages

Andersen, R S

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.

Cancer immunology, immunotherapy : CII; 60(2) pg227-34

0 Feb 2011

20981424
Show Usages

Merlo, A

Impact of Î³-chain cytokines on EBV-specific T cell cultures.

Journal of Translational Medicine; 8 pg121

22 Nov 2010

21092174
Show Usages

Janikashvili, N

Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.

Blood; 117(5) pg1555-64

3 Feb 2011

21123824
Show Usages

Feng, N

Lineage divergence at the first TCR-dependent checkpoint: preferential Î³Î´ and impaired Î±Î² T cell development in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950); 186(2) pg826-37

15 Jan 2011

21148803
Show Usages

Sun, H

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood; 117(11) pg3151-62

17 Mar 2011

21248063
Show Usages

Awong, G

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

BMC Immunology; 12 pg22

23 Mar 2011

21429219
Show Usages

Kurtulus, S

Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Journal of immunology (Baltimore, Md. : 1950); 186(10) pg5729-37

15 May 2011

21451108
Show Usages

Bondanza, A

IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.

Blood; 117(24) pg6469-78

16 Jun 2011

21531977
Show Usages

Amarnath, S

Host-based Th2 cell therapy for prolongation of cardiac allograft viability.

PLoS ONE; 6(4) pge18885

29 Apr 2011

21559526
Show Usages

Duy, C

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.

Nature; 473(7347) pg384-8

19 May 2011

21593872
Show Usages

Bluteau, D

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Blood; 118(24) pg6310-20

8 Dec 2011

21725049
Show Usages

Zhan, Y

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950); 187(4) pg1566-77

15 Aug 2011

21742968
Show Usages

Park, Y P

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the Î³c cytokines and TGF-Î²1.

Blood; 118(11) pg3019-27

15 Sep 2011

21816829
Show Usages

Bosque, A

Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells.

PLoS Pathogens; 7(10) pge1002288

0 Oct 2011

21998586
Show Usages

Chen, H

Activation of STAT6 by STING is critical for antiviral innate immunity.

Cell; 147(2) pg436-46

14 Oct 2011

22000020
Show Usages

Muralidharan, S

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950); 187(10) pg5221-32

15 Nov 2011

22013128
Show Usages

Takata, H

Functional heterogeneity of human effector CD8+ T cells.

Blood; 119(6) pg1390-8

9 Feb 2012

22174157
Show Usages

Sammicheli, S

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-Î³/STAT1 pathway.

PLoS ONE; 6(12) pge28629

0 2011

22194871
Show Usages

Chiang, C L

Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.

PLoS ONE; 6(12) pge28732

0 2011

22194898
Show Usages

Yu, Y

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

PLoS ONE; 6(12) pge28948

0 2011

22194954
Show Usages

Sjeklocha, L M

Erythroid-specific expression of Î²-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.

PLoS ONE; 6(12) pge29110

0 2011

22216176
Show Usages

Paine, A

IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.

Journal of immunology (Baltimore, Md. : 1950); 188(4) pg1620-9

15 Feb 2012

22246628
Show Usages

Kreft, K L

The IL-7RÎ± pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950); 188(4) pg1874-83

15 Feb 2012

22262655
Show Usages

Tanaka, Y

Early ontogenic origin of the hematopoietic stem cell lineage.

Proceedings of the National Academy of Sciences of the United States of America; 109(12) pg4515-20

20 Mar 2012

22392989
Show Usages

Mitra, A

Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.

The Journal of Biological Chemistry; 287(20) pg16596-608

11 May 2012

22442148
Show Usages

Ridges, S

Zebrafish screen identifies novel compound with selective toxicity against leukemia.

Blood; 119(24) pg5621-31

14 Jun 2012

22490804
Show Usages

Karrich, J J

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Blood; 119(22) pg5191-200

31 May 2012

22510878
Show Usages

Liu, D

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.

The Journal of Clinical Investigation; 122(6) pg2221-33

0 Jun 2012

22565311
Show Usages

Hoorweg, K

Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells.

Frontiers in Immunology; 3 pg72

0 2012

22566953
Show Usages

Lissauer, D

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Journal of immunology (Baltimore, Md. : 1950); 189(2) pg1072-80

15 Jul 2012

22685312
Show Usages

Reimann, C

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/Î³c(-/-) mice.

Stem cells (Dayton, Ohio); 30(8) pg1771-80

0 Aug 2012

22689616
Show Usages

Chang, K H

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

Blood; 120(4) pg800-11

26 Jul 2012

22692505
Show Usages

Katara, G K

Evidence for involvement of Th17 type responses in post kala azar dermal leishmaniasis (PKDL).

PLoS Neglected Tropical Diseases; 6(6) pge1703

0 2012

22724038
Show Usages

Rabenhorst, A

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood; 120(10) pg2042-54

6 Sep 2012

22837530
Show Usages

Cimbro, R

IL-7 induces expression and activation of integrin Î±4Î²7 promoting naive T-cell homing to the intestinal mucosa.

Blood; 120(13) pg2610-9

27 Sep 2012

22896005
Show Usages

Patel, E S

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC Immunology; 13 pg46

16 Aug 2012

22897934
Show Usages

Bilwani, F A

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950); 189(9) pg4379-86

1 Nov 2012

23002443
Show Usages

Demachi-Okamura, A

Autophagy creates a CTL epitope that mimics tumor-associated antigens.

PLoS ONE; 7(10) pge47126

0 2012

23071732
Show Usages

Blix, E S

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.

BMC Cancer; 12 pg478

16 Oct 2012

23072591
Show Usages

van de Laar, L

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

Blood; 120(25) pg4982-91

13 Dec 2012

23091295
Show Usages

Testa, J S

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PLoS ONE; 7(11) pge48484

0 2012

23144892
Show Usages

Cieri, N

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

Blood; 121(4) pg573-84

24 Jan 2013

23160470
Show Usages

Amabile, G

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Blood; 121(8) pg1255-64

21 Feb 2013

23212524
Show Usages

Munir, S

Characterization of T-cell responses against IÎºBÎ± in cancer patients.

Oncoimmunology; 1(8) pg1290-1296

1 Nov 2012

23243592
Show Usages

Magnusson, M

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PLoS ONE; 8(1) pge53912

0 2013

23342037
Show Usages

Tallerico, R

Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.

Journal of immunology (Baltimore, Md. : 1950); 190(5) pg2381-90

1 Mar 2013

23345327
Show Usages

Mace, E M

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Blood; 121(14) pg2669-77

4 Apr 2013

23365458
Show Usages

Kuijk, L M

Notch controls generation and function of human effector CD8+ T cells.

Blood; 121(14) pg2638-46

4 Apr 2013

23380742
Show Usages

Introini, A

Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.

PLoS Pathogens; 9(2) pge1003148

0 Feb 2013

23408885
Show Usages

Schilling, B

IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells.

PLoS ONE; 8(2) pge47234

0 2013

23408925
Show Usages

Choi, Y S

Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.

Journal of immunology (Baltimore, Md. : 1950); 190(8) pg4014-26

15 Apr 2013

23487426
Show Usages

Miyazaki, Y

Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.

Blood; 121(24) pg4894-901

13 Jun 2013

23641014
Show Usages

Kyoizumi, S

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Journal of immunology (Baltimore, Md. : 1950); 190(12) pg6164-72

15 Jun 2013

23670190
Show Usages

Henry-Bonami, R A

B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950); 190(12) pg5992-6003

15 Jun 2013

23677466
Show Usages

Koss, B

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.

Blood; 122(9) pg1587-98

29 Aug 2013

23881917
Show Usages

Fernandez, I

Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.

Stem cells (Dayton, Ohio); 32(1) pg93-104

0 Jan 2014

23939944
Show Usages

Li, L

Differential response of regulatory and conventional CD4âº lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?

Journal of immunology (Baltimore, Md. : 1950); 191(7) pg3694-704

1 Oct 2013

23986534
Show Usages

Casucci, M

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Blood; 122(20) pg3461-72

14 Nov 2013

24016461
Show Usages

Bonami, R H

Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.

Journal of immunology (Baltimore, Md. : 1950); 192(4) pg1459-70

15 Feb 2014

24453243
Show Usages

Du, M

Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.

Journal of immunology (Baltimore, Md. : 1950); 192(4) pg1502-11

15 Feb 2014

24453244
Show Usages

Kim, P S

Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.

Journal of immunology (Baltimore, Md. : 1950); 192(6) pg2622-33

15 Mar 2014

24516200
Show Usages

Morandi, F

IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.

Journal of immunology (Baltimore, Md. : 1950); 192(6) pg2634-42

15 Mar 2014

24554774
Show Usages

Gang, A O

5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.

Blood Cancer Journal; 4 pge197

28 Mar 2014

24681961
Show Usages

Nair, S K

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific Reports; 4 pg4632

23 Apr 2014

24755960
Show Usages

Xu, Y

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.

Blood; 123(24) pg3750-9

12 Jun 2014

24782509
Show Usages

Miller, M L

Basal NF-ÎºB controls IL-7 responsiveness of quiescent naÃ¯ve T cells.

Proceedings of the National Academy of Sciences of the United States of America; 111(20) pg7397-402

20 May 2014

24799710
Show Usages

Genovese, P

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature; 510(7504) pg235-240

12 Jun 2014

24870228
Show Usages

Zhang, S L

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.

Blood; 124(2) pg296-304

10 Jul 2014

24876562
Show Usages

Zhao, L

Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.

Journal of immunology (Baltimore, Md. : 1950); 193(2) pg735-45

15 Jul 2014

24943214
Show Usages

Qi, Q

Diversity and clonal selection in the human T-cell repertoire.

Proceedings of the National Academy of Sciences of the United States of America; 111(36) pg13139-44

9 Sep 2014

25157137
Show Usages

Nazzal, D

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand.

Cell death & disease; 5 pge1420

11 Sep 2014

25210803
Show Usages

Stephen, T L

Transforming growth factor Î²-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity; 41(3) pg427-439

18 Sep 2014

25238097
Show Usages

Pan, Q

Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.

Stem cells (Dayton, Ohio); 33(2) pg354-66

0 Feb 2015

25267273
Show Usages

Laffont, S

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-Î± production of plasmacytoid dendritic cells from women.

Journal of immunology (Baltimore, Md. : 1950); 193(11) pg5444-52

1 Dec 2014

25339659
Show Usages

Arber, C

Survivin-specific T cell receptor targets tumor but not T cells.

The Journal of Clinical Investigation; 125(1) pg157-68

0 Jan 2015

25415440
Show Usages

Salio, M

Essential role for autophagy during invariant NKT cell development.

Proceedings of the National Academy of Sciences of the United States of America; 111(52) pgE5678-87

30 Dec 2014

25512546
Show Usages

Ferrell, P I

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio); 33(4) pg1130-41

0 Apr 2015

25546363
Show Usages

Geskin, L J

Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.

Blood; 125(18) pg2798-805

30 Apr 2015

25628470
Show Usages

McClellan, J S

Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.

Proceedings of the National Academy of Sciences of the United States of America; 112(13) pg4074-9

31 Mar 2015

25775523
Show Usages

Nagai, Y

T memory stem cells are the hierarchical apex of adult T-cell leukemia.

Blood; 125(23) pg3527-35

4 Jun 2015

25847015
Show Usages

Vamos, C A

Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.

Journal of community health; 40(6) pg1047-56

0 Dec 2015

25947012
Show Usages

Wegner, J

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.

Blood; 126(2) pg185-94

9 Jul 2015

26024876
Show Usages

Allam, A

TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1.

Scientific Reports; 5 pg10443

2 Jun 2015

26034905
Show Usages

Leone, P

Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.

Blood; 126(12) pg1443-51

17 Sep 2015

26185130
Show Usages

Chen, Q

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific Reports; 5 pg15118

12 Oct 2015

26456148
Show Usages

Bending, D

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.

Journal of immunology (Baltimore, Md. : 1950); 195(12) pg5616-24

15 Dec 2015

26561546
Show Usages

Yin, J

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America; 112(52) pg15988-93

29 Dec 2015

26668377
Show Usages

D'Souza, S S

GSK3Î² Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem Cell Reports; 6(2) pg243-56

9 Feb 2016

26805448
Show Usages

Serr, I

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Nature Communications; 7 pg10991

15 Mar 2016

26975663
Show Usages

Korfi, K

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.

Cell death & disease; 7 pge2177

7 Apr 2016

27054332
Show Usages

Grier, A E

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.

Molecular therapy. Nucleic acids; 5 pge306

19 Apr 2016

27093168
Show Usages

Gomez-Cadena, A

Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model.

Cell death & disease; 7(6) pge2243

2 Jun 2016

27253407
Show Usages

Dan, J M

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

Journal of immunology (Baltimore, Md. : 1950); 197(3) pg983-93

1 Aug 2016

27342848
Show Usages

Woytschak, J

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Immunity; 45(1) pg172-84

19 Jul 2016

27438770
Show Usages

Galaine, J

Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950); 197(5) pg1597-608

1 Sep 2016

27481844
Show Usages

Kagoya, Y

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.

The Journal of Clinical Investigation; 126(9) pg3479-94

1 Sep 2016

27548527
Show Usages

Lykken, E A

The MicroRNA miR-191 Supports T Cell Survival Following Common Î³ Chain Signaling.

The Journal of Biological Chemistry; 291(45) pg23532-23544

4 Nov 2016

27634043
Show Usages

Amabile, A

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing.

Cell; 167(1) pg219-232.e14

22 Sep 2016

27662090
Show Usages

Romano Ibarra, G S

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Molecular therapy. Nucleic acids; 5(8) pge352

23 Aug 2016

27741222
Show Usages

Gregory, M A

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America; 113(43) pgE6669-E6678

25 Oct 2016

27791036
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Cuff, A O

Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Journal of immunology (Baltimore, Md. : 1950); 197(11) pg4283-4291

1 Dec 2016

27798170
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Bassani-Sternberg, M

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature Communications; 7 pg13404

21 Nov 2016

27869121
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Abolhassani, H

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

The Journal of Experimental Medicine; 214(1) pg91-106

0 Jan 2017

28011864
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Belderbos, M E

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding.

Blood; 129(24) pg3210-3220

15 Jun 2017

28396495
Show Usages

Delgado-Martin, C

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.

Leukemia; 31(12) pg2568-2576

0 Dec 2017

28484265
Show Usages

Schmueck-Henneresse, M

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.

Journal of immunology (Baltimore, Md. : 1950); 199(1) pg348-362

1 Jul 2017

28550199
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Das, A

Adaptive from Innate: Human IFN-Î³

Journal of immunology (Baltimore, Md. : 1950); 199(5) pg1696-1705

1 Sep 2017

28754679
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Li, Y

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Stem Cell Reports; 9(3) pg779-795

12 Sep 2017

28803914
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Minami, H

CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.

Journal of immunology (Baltimore, Md. : 1950); 199(7) pg2343-2355

1 Oct 2017

28842468
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Ucar, D

The chromatin accessibility signature of human immune aging stems from CD8

The Journal of Experimental Medicine; 214(10) pg3123-3144

2 Oct 2017

28904110
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Park, S

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.

Scientific Reports; 7(1) pg14366

30 Oct 2017

29085043
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Serafin, V

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.

Blood; 130(25) pg2750-2761

21 Dec 2017

29101238
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Nastasi, C

Butyrate and propionate inhibit antigen-specific CD8

Scientific Reports; 7(1) pg14516

6 Nov 2017

29109552
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Sabins, N C

TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.

Journal of immunology (Baltimore, Md. : 1950); 199(12) pg4091-4102

15 Dec 2017

29127145
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Ripamonti, A

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.

Proceedings of the National Academy of Sciences of the United States of America; 114(48) pg12797-12802

28 Nov 2017

29133396
Show Usages

Robles-Valero, J

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer Cell; 32(5) pg608-623.e9

13 Nov 2017

29136506
Show Usages

Al-Mossawi, M H

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Nature Communications; 8(1) pg1510

15 Nov 2017

29142230
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Zeng, J

Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.

Stem Cell Reports; 9(6) pg1796-1812

12 Dec 2017

29173894
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Akondy, R S

Origin and differentiation of human memory CD8 T cells after vaccination.

Nature; 552(7685) pg362-367

21 Dec 2017

29236685
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Kim, J

Innate-like Cytotoxic Function of Bystander-Activated CD8

Immunity; 48(1) pg161-173.e5

16 Jan 2018

29305140
Show Usages

Booth, C A

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer Cell; 33(2) pg274-291.e8

12 Feb 2018

29438697
Show Usages

Li, N

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

The Journal of Experimental Medicine; 215(5) pg1383-1396

7 May 2018

29511064
Show Usages

Uenishi, G I

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature Communications; 9(1) pg1828

8 May 2018

29739946
Show Usages

MacLean, G A

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific Reports; 8(1) pg8001

22 May 2018

29789608
Show Usages

Ueda, N

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.

Stem Cell Reports; 10(6) pg1935-1946

5 Jun 2018

29805109
Show Usages

Bando, J K

The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.

Immunity; 48(6) pg1208-1219.e4

19 Jun 2018

29858011
Show Usages

Hosokawa, H

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Immunity; 48(6) pg1119-1134.e7

19 Jun 2018

29924977
Show Usages

Badia, R

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.

Nature Communications; 9(1) pg2739

16 Jul 2018

30013105
Show Usages

Helsen, C W

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.

Nature Communications; 9(1) pg3049

3 Aug 2018

30076299
Show Usages

Lee, J K

Directed evolution of CRISPR-Cas9 to increase its specificity.

Nature Communications; 9(1) pg3048

6 Aug 2018

30082838
Show Usages

Aue, G

Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.

Journal of immunology (Baltimore, Md. : 1950); 201(7) pg1967-1974

1 Oct 2018

30104242
Show Usages

Ngai, H

IL-21 Selectively Protects CD62L

Journal of immunology (Baltimore, Md. : 1950); 201(7) pg2141-2153

1 Oct 2018

30111631
Show Usages

Laustsen, A

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

Nature Communications; 9(1) pg3525

30 Aug 2018

30166549
Show Usages

Kauts, M

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem Cell Reports; 11(4) pg1009-1020

9 Oct 2018

30197119
Show Usages

Mudd, J C

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Nature Communications; 9(1) pg3967

27 Sep 2018

30262807
Show Usages

Vasko, T

Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.

Scientific Reports; 8(1) pg16903

15 Nov 2018

30443001
Show Usages

Hanson, M G

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71

15 Sep 1998

9736656
Show Usages

Wang, R

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

Science (New York, N.Y.); 282(5388) pg476-80

16 Oct 1998

9774275
Show Usages

Yu, H

Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.

Blood; 92(10) pg3647-57

15 Nov 1998

9808558
Show Usages

Shah, N

Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment.

Blood; 92(10) pg3817-28

15 Nov 1998

9808575
Show Usages

Conway, K A

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

Nature Medicine; 4(11) pg1318-20

0 Nov 1998

9809558
Show Usages

Gerdemann, U

Generation of multivirus-specific T cells to prevent/treat viral infections after allogeneic hematopoietic stem cell transplant.

Journal of visualized experiments : JoVE; 51(51)

27 May 2011

21654628
Show Usages

Sørensen, R B

Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.

Blood; 117(7) pg2200-10

17 Feb 2011

21079151
Show Usages

Lünemann, J D

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2.

The Journal of Experimental Medicine; 205(8) pg1763-73

4 Aug 2008

18663124
Show Usages

Volonté, A

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.

Journal of immunology (Baltimore, Md. : 1950); 192(1) pg523-32

1 Jan 2014

24277698
Show Usages

Wölfl, M

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Blood; 122(7) pg1203-13

15 Aug 2013

23836556
Show Usages

Sørensen, R B

The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.

PLoS ONE; 4(9) pge6910

7 Sep 2009

19738905
Show Usages

Clénet, M

Peripheral human CD4

Scientific Reports; 7(1) pg11612

14 Sep 2017

28912605
Show Usages

Sørensen, R B

Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.

Blood; 117(7) pg2200-10

17 Feb 2011

21079151
Show Usages

Volonté, A

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.

Journal of immunology (Baltimore, Md. : 1950); 192(1) pg523-32

1 Jan 2014

24277698
Show Usages

Wölfl, M

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Blood; 122(7) pg1203-13

15 Aug 2013

23836556
Show Usages

Lünemann, J D

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2.

The Journal of Experimental Medicine; 205(8) pg1763-73

4 Aug 2008

18663124
Show Usages

Sørensen, R B

The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.

PLoS ONE; 4(9) pge6910

7 Sep 2009

19738905
Show Usages

Clénet, M

Peripheral human CD4

Scientific Reports; 7(1) pg11612

14 Sep 2017

28912605
Show Usages

Akkapeddi, P

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

ACS Medicinal Chemistry Letters;

8 Mar 2019

30850736
Show Usages

Meng, X

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature; 564(7734) pg130-135

1 Dec 2018

30487606
Show Usages

Luong-Gardiol, N

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

Cancer Cell; 35(4) pg649-663.e10

15 Apr 2019

30991025
Show Usages

Weijenborg Campos, L

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Blood; 133(11) pg1259-1263

14 Mar 2019

30670441
Show Usages

Du, H

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.

Cancer Cell; 35(2) pg221-237.e8

11 Feb 2019

30753824
Show Usages

Nayak, R

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nature Communications; 10(1) pg46

4 Jan 2019

30610188
Show Usages

Parks, C

Breaking tolerance with engineered class I antigen-presenting molecules.

Proceedings of the National Academy of Sciences of the United States of America; 116(8) pg3136-3145

19 Feb 2019

30728302
Show Usages

Mesquitta, W

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.

Scientific Reports; 9(1) pg6622

29 Apr 2019

31036928
Show Usages

Pavel-Dinu, M

Gene correction for SCID-X1 in long-term hematopoietic stem cells.

Nature Communications; 10(1) pg1634

9 Apr 2019

30967552
Show Usages

Fan, J

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.

Nature Communications; 10(1) pg2257

21 May 2019

31113957
Show Usages

Zhang, Z

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

The Journal of Experimental Medicine; 216(6) pg1311-1327

3 Jun 2019

31040185
Show Usages

Seol, M

Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition.

Scientific Reports; 9(1) pg6917

6 May 2019

31061414
Show Usages

Growth Factors & Cytokines