Recombinant Human IL-8 (CXCL8) (72 a.a.)

제품 상세

카다로그 번호 200-08M

제품 설명

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: CXCL8, monocyte-derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), NAP-1

AA Sequence: SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Cross Reactivity:

Bacteria, Human , Human + Rat, Monkey, Mouse, N/A, Rat

Research Interest

Angiogenesis/Cardiovascular

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

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22 Apr 1999

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Gasser, O

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Ulfman, L H

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Munitz, A

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Smith, P

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21 Nov 2005

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Lokshin, A E

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Van den Steen, P E

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Takahashi, M

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Draing, C

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Aranami, T

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Gasser, O

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15 Dec 2006

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Proost, P

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1 Jul 2007

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Gueinzius, K

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9 Jun 2008

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26 Sep 2008

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15 Aug 2008

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7 Nov 2008

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CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

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15 Nov 2008

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The IgG-specific endoglycosidase EndoS inhibits both cellular and complement-mediated autoimmune hemolysis.

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15 Sep 2010

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Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

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Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.

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Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

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29 Apr 2011

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TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.

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1 Sep 2011

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L-selectin and SDF-1 enhance the migration of mouse and human cardiac mesoangioblasts.

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EBF and dried blood spots: from recommendations to potential resolution.

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Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation.

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MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.

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Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.

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ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF-ÎºB activation.

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17 May 2012

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Futosi, K

Dasatinib inhibits proinflammatory functions of mature human neutrophils.

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Surewaard, B G

Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles.

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Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.

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Chiappini, N

Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model.

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Raghuwanshi, S K

The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.

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15 Sep 2012

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Dwyer, J

Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2.

PLoS ONE; 7(9) pge45562

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Rossaint, J

Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade.

PLoS ONE; 7(9) pge45738

0 2012

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Madenspacher, J H

Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.

The Journal of Biological Chemistry; 287(52) pg43730-40

21 Dec 2012

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Sachdeva, R

Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.

PLoS ONE; 7(11) pge51125

0 2012

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Whittall, C

A chemokine self-presentation mechanism involving formation of endothelial surface microstructures.

Journal of immunology (Baltimore, Md. : 1950); 190(4) pg1725-36

15 Feb 2013

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Herter, J M

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling.

Blood; 121(12) pg2301-10

21 Mar 2013

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Herlihy, S E

Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.

Journal of immunology (Baltimore, Md. : 1950); 190(12) pg6468-77

15 Jun 2013

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Berger, C

Lidocaine reduces neutrophil recruitment by abolishing chemokine-induced arrest and transendothelial migration in septic patients.

Journal of immunology (Baltimore, Md. : 1950); 192(1) pg367-76

1 Jan 2014

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Pei, X

PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.

Journal of immunology (Baltimore, Md. : 1950); 192(4) pg1878-86

15 Feb 2014

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Pallasch, C P

Sensitizing protective tumor microenvironments to antibody-mediated therapy.

Cell; 156(3) pg590-602

30 Jan 2014

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Parlato, M

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.

Journal of immunology (Baltimore, Md. : 1950); 192(5) pg2449-59

1 Mar 2014

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Singh, V

G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions.

Journal of immunology (Baltimore, Md. : 1950); 192(5) pg2186-94

1 Mar 2014

24510965
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Konya, V

A biased non-GÎ±i OXE-R antagonist demonstrates that GÎ±i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.

Journal of immunology (Baltimore, Md. : 1950); 192(10) pg4774-82

15 May 2014

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Su, S

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Cancer Cell; 25(5) pg605-20

12 May 2014

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Chen, C

Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.

Scientific Reports; 4 pg6359

15 Sep 2014

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Lourenco, S

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Journal of immunology (Baltimore, Md. : 1950); 194(7) pg3463-74

1 Apr 2015

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Stadtmann, A

Cross-Talk between Shp1 and PIPKIÎ³ Controls Leukocyte Recruitment.

Journal of immunology (Baltimore, Md. : 1950); 195(3) pg1152-61

1 Aug 2015

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De Buck, M

Serum amyloid A1Î± induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.

Journal of Leukocyte Biology; 98(6) pg1049-60

0 Dec 2015

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Rossaint, J

FGF23 signaling impairs neutrophil recruitment and host defense during CKD.

The Journal of Clinical Investigation; 126(3) pg962-74

1 Mar 2016

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Almeida, C R

NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment.

Stem Cell Reports; 6(4) pg466-473

12 Apr 2016

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Karjalainen, R

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

Blood; 130(6) pg789-802

10 Aug 2017

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Kosaisavee, V

Strict tropism for CD71

Blood; 130(11) pg1357-1363

14 Sep 2017

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Yang, L

IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity.

American Journal of Physiology. Lung Cellular and Molecular Physiology; 314(1) pgL127-L136

1 Jan 2018

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De Buck, M

COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.

Blood; 131(4) pg439-449

25 Jan 2018

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Schuster, M

Surveillance of Myelodysplastic Syndrome via Migration Analyses of Blood Neutrophils: A Potential Prognostic Tool.

Journal of immunology (Baltimore, Md. : 1950); 201(12) pg3546-3557

15 Dec 2018

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Sarafi, M N

Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.

The Journal of Experimental Medicine; 185(1) pg99-109

6 Jan 1997

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Nieto, M

Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis.

The Journal of Experimental Medicine; 186(1) pg153-8

7 Jul 1997

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Tiffany, H L

Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.

The Journal of Experimental Medicine; 186(1) pg165-70

7 Jul 1997

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Middleton, J

Transcytosis and surface presentation of IL-8 by venular endothelial cells.

Cell; 91(3) pg385-95

31 Oct 1997

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Yoshida, T

Identification of single C motif-1/lymphotactin receptor XCR1.

The Journal of Biological Chemistry; 273(26) pg16551-4

26 Jun 1998

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Hamada, T

Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.

The Journal of Experimental Medicine; 188(3) pg539-48

3 Aug 1998

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Khandaker, M H

CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950); 161(4) pg1930-8

15 Aug 1998

9712063
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Kuhns, D B

Ca2+-dependent production and release of IL-8 in human neutrophils.

Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4332-9

15 Oct 1998

9780210
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Petersen, F

A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation.

Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4347-55

15 Oct 1998

9780212
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van den Berg, R H

The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells.

Journal of immunology (Baltimore, Md. : 1950); 161(12) pg6924-30

15 Dec 1998

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