Recombinant Human OPG 0 리뷰submitareview 제품 상세 카다로그 번호 450-14 제품 설명 Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues. Source: E.coli Synonyms: TNFRSF11B, Osteoprotegerin, OCIF (osteoclastogenesis inhibitory factor), TR1 AA Sequence: METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells. Calculated Molecular Weight: 20 kDa Accession Number: O00300 Gene ID: 4982 crossreactivity: Human, Mouse, Rat Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cancer Immune System Receptors TNF Superfamily References PubMed SDS Product Line Country Of Origin: USA Not for human use.
