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Growth Factors & Cytokines

Recombinant Human PDGF-AB

제품 상세

카다로그 번호 100-00AB
제품 설명

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids).

Source: E.coli

Synonyms: Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF

AA Sequence: Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT
Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Calculated Molecular Weight: 26.4 kDa

Accession Number: Alpha: P04085 Beta: P01127

Gene ID: Alpha: 5154 Beta: 5155

crossreactivity: Research Interest

Country Of Origin: USA

Not for human use.

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기존 리뷰
Easy to reconstitute and store for long-term usage
The item came fast, it's easy to reconstitute and there's enough options to indicate storage and usage at given temperatures. It's worked well in a variety of assays and I will continue to use this product.
에서:  Vikram | 날짜:  2020-07-22