Recombinant Human R-Spondin-1 4 리뷰Submit a Review 제품 상세 카다로그 번호 120-38 제품 설명 R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/β-catenin signaling pathway. Recombinant Human R-Spondin-1 is a 26.7 kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions. Source: CHO cells Synonyms: Roof plate-specific spondin-1, RSPO1 AA Sequence: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 is 1.0-3.0 μg/ml. Calculated Molecular Weight: 26.7 kDa Accession Number: Q2MKA7 Gene ID: 284654 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Cancer Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations 제 1 저자 Yoon, Y 주제 Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands. 인용 Nature Communications; 13(1) pg3291 PubMed ID 35672412 제 1 저자 Ryu, T Y 주제 Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer. 인용 The ISME Journal; 16(5) pg1205-1221 PubMed ID 34972816 제 1 저자 Buchanan, K L 주제 The preference for sugar over sweetener depends on a gut sensor cell. 인용 Nature Neuroscience; 25(2) pg191-200 PubMed ID 35027761 product.subtitle.productreviews 기존 리뷰 Perfect for organoid culture My lung organoids grow well consistently even after passaging it couple of times and there were no contamination issues. 에서: Eun Joo | 날짜: 2020-07-08 × Perfect for organoid culture My lung organoids grow well consistently even after passaging it couple of times and there were no contamination issues. 에서: Eun Joo | 날짜: 2020-07-08 Close Good for organoid This is good for my primary lung organoid culture. 에서: Jun | 날짜: 2020-07-21 × Good for organoid This is good for my primary lung organoid culture. 에서: Jun | 날짜: 2020-07-21 Close High quality and good price This product worked well for my project. The price is reasonable and lower than most of vendors. 에서: Jin | 날짜: 2020-08-26 × High quality and good price This product worked well for my project. The price is reasonable and lower than most of vendors. 에서: Jin | 날짜: 2020-08-26 Close Excellent qualiity We have been using recombinant human R-spondin-1 for over 6 years and have been absolutely satisfied with the quality, purity, and performance! 에서: Candace | 날짜: 2021-08-03 × Excellent qualiity We have been using recombinant human R-spondin-1 for over 6 years and have been absolutely satisfied with the quality, purity, and performance! 에서: Candace | 날짜: 2021-08-03 Close
