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Growth Factors & Cytokines

Recombinant Human TGF-β1 (HEK293 derived)

제품 상세

카다로그 번호 100-21
제품 설명

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 derived from HEK293 cells is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

Source: HEK293 cells

Synonyms: Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor

AA Sequence (monomer): ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

Calculated Molecular Weight: 25 kDa

Accession Number: P01137

Gene ID: 7040

crossreactivity: Research Interest

Country Of Origin: USA

Not for human use.

product.subtitle.productreviews

기존 리뷰
Good quality price for the best results
We have been using this reagent for years for creating neo cartilage from our chondrocytes and MSCs with very satisfactory results! I'd completely recommend it.
에서:  Alejandro | 날짜:  2020-07-09
For Treg induction
Very good for experiments with induced regulatory T cells, enables efficient induction of human Treg at 10-20ng/ml. Consistent across lots.
에서:  Julian | 날짜:  2020-07-10
Good for EMT induction
We have been using it for years to induce EMT in human primary small airway epithelial cells.
에서:  Jun | 날짜:  2020-07-21
Good!
Worked as Described!
에서:  Lillian | 날짜:  2020-07-21
Good and cheap
Works quite well in organoid cultures and it's for a very reasonable price.
에서:  Saana | 날짜:  2020-07-29
Works well to induce collagen and GAG production in neocartilage
Our group has used this product for years and we are always pleased with the outcome in our systems. Batch to batch variation is very low and works consistently in culturing neocartilage with the intent to repair focal cartilage defects.
에서:  Ryan | 날짜:  2020-08-21
Good quality product
Thank you for providing us good quality cytokines with resonable price and fast delivery. Appreciate your service during Covid times. Quality of the product is excellent.
에서:  Deepti | 날짜:  2020-08-31
Quality Growth Factor for mesenchymal (EMT) signaling
I used for Organoid Culture with mesenchymal signaling.
Needed for squamous type of organoid growth.
에서:  Hardik | 날짜:  2020-08-31