Recombinant Human TGF-β3 0 리뷰Submit a Review 제품 상세 카다로그 번호 100-36E 제품 설명 The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Source: E.coli Synonyms: Transforming Growth Factor-β3 AA Sequence (monomer): ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 25 kDa Accession Number: P10600 Gene ID: 7043 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Cow, Dog, Horse, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat, Sheep References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation TGF-β Superfamily Wound Healing Allergy product.subtitle.recentcitations 제 1 저자 Sabate-Soler, S 주제 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 인용 Glia; 70(7) pg1267-1288 PubMed ID 35262217 제 1 저자 Hanuscheck, N 주제 Interleukin-4 receptor signaling modulates neuronal network activity. 인용 The Journal of Experimental Medicine; 219(6) PubMed ID 35587822 제 1 저자 Rasińska, J 주제 Transposon-mediated glial cell line-derived neurotrophic factor overexpression in human adipose tissue-derived mesenchymal stromal cells: A potential approach for neuroregenerative medicine? 인용 Journal Of Tissue Engineering And Regenerative Medicine; 16(6) pg515-529 PubMed ID 35278347