Recombinant Human TNF-β

제품 상세

카다로그 번호 300-01B

제품 설명

TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands, and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α. Like TNF-α, TNF-β is involved in the regulation of various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant Human TNF-β is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide-linked homotrimer structure in solution.

Source: E.coli

Synonyms: Tumor Necrosis Factor-β, TNFSF1B, Lymphotoxin-alpha (LT-α)

AA Sequence: MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

Calculated Molecular Weight: 18.6 kDa

Accession Number: P01374

Gene ID: 4049

Note:

1mg will be provided as 2x500μg.

crossreactivity:

Mouse

Research Interest

Stem Cells & Differentiation

TNF Superfamily

Angiogenesis/Cardiovascular

Country Of Origin: USA

Not for human use.

Products Cited

Cross-Reactivity

Applications

200-01B, 200-02, 200-04, 200-05, 200-06, 200-08M, 300-01A, 300-01B, 300-02, 300-03, 200-10, 300-21,

Human

in vitro

Products Cited

Cross-Reactivity

Applications

217-17, 315-05, 211-11B, 315-01A, 300-01B,

Mouse

in vitro

Products Cited

Cross-Reactivity

Applications

100-13A, 100-00AB, 100-14B, 300-02, 300-01A, 300-01B, 300-12, 300-06, 100-20,

Human

in vitro

Products Cited

Cross-Reactivity

Applications

300-01B,

Mouse

in vitro

300-01B, 500-P31A, 500-P31B,

Mouse

Neutralization

Products Cited

Cross-Reactivity

Applications

300-01B,

Mouse

in vitro

Products Cited

Cross-Reactivity

Applications

300-01A, 300-01B, 315-01A,

Mouse

in vitro

315-15, 315-19, 315-11, 315-13, 315-12,

N/A

Binding Assay

Products Cited

Cross-Reactivity

Applications

300-02BC, 300-02J, 300-25, 300-01B,

Human

in vitro

Products Cited

Cross-Reactivity

Applications

300-02, 300-07, 200-06, 300-25, 300-26, 300-08, 300-01A, 300-01B, 100-14B,

Human

in vitro

Products Cited

Cross-Reactivity

Applications

120-40, 120-05, 100-50, 300-28A, 120-30, AF-100-15, 100-26, 100-18B, 100-30, 120-01, 450-10, 300-02, 100-11, 200-01A, 200-06, 300-07, 300-01B, 450-01, 100-03, 300-10T, 100-14B, 100-00CC, 100-07, 100-21C, 450-33,

Human

in vitro

100-18B,

Mouse

in vivo

Products Cited

Cross-Reactivity

Applications

300-01B, 315-01A,

Mouse

in vitro

Growth Factors & Cytokines