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Neurotrophins

Recombinant Human/Murine/Rat BDNF

제품 상세

카다로그 번호 450-02
제품 설명

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.

Source: E.coli

Synonyms: Brain Derived Neurotrophic Factor, Abrineurin

AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.

Calculated Molecular Weight: 27 kDa

Accession Number: P23560

Gene ID: 627

crossreactivity: Research Interest

Country Of Origin: USA

Not for human use.

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기존 리뷰
I have used PeproTech BDNF since 2012
I have used PeproTech BDNF at Stanford and Genentech since 2012 and it has been great for differentiating stem cells into neurons. It is the best product in this category of recombinant proteins.
에서:  Louise | 날짜:  2020-08-21
Supports Growth of Cholinergic Neurons
Routinely use this to support and maintain primary murine cholinergic neurons in culture. Excellent product.
에서:  Bernadeta | 날짜:  2020-08-26
Differentiation and support of SH-SY5Y cells
I have been using this product for over 3 years now to support and differentiate SH-SY5Y cells in culture. It is an excellent product that many people in my lab use. It always works well and is reliable.
에서:  Crystal | 날짜:  2020-08-29