Recombinant Human/Murine/Rat BDNF 7 리뷰Submit a Review 제품 상세 카다로그 번호 450-02 제품 설명 BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Source: E.coli Synonyms: Brain Derived Neurotrophic Factor, Abrineurin AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 27 kDa Accession Number: P23560 Gene ID: 627 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Chicken, Frog, Guinea Pig, Hamster, Human, Human + Mouse, Human + Rat, Human + Virus, Monkey, Mouse, Rat, Tadpole, tests References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations 제 1 저자 Pantazis, C B 주제 A reference human induced pluripotent stem cell line for large-scale collaborative studies. 인용 Cell Stem Cell; 29(12) pg1685-1702.e22 PubMed ID 36459969 제 1 저자 Kaluscha, S 주제 Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation. 인용 Nature Genetics; 54(12) pg1895-1906 PubMed ID 36471082 제 1 저자 Mesci, P 주제 SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. 인용 PLoS Biology; 20(11) pge3001845 PubMed ID 36327326 product.subtitle.productreviews 기존 리뷰 I have used PeproTech BDNF since 2012 I have used PeproTech BDNF at Stanford and Genentech since 2012 and it has been great for differentiating stem cells into neurons. It is the best product in this category of recombinant proteins. 에서: Louise | 날짜: 2020-08-21 × I have used PeproTech BDNF since 2012 I have used PeproTech BDNF at Stanford and Genentech since 2012 and it has been great for differentiating stem cells into neurons. It is the best product in this category of recombinant proteins. 에서: Louise | 날짜: 2020-08-21 Close Supports Growth of Cholinergic Neurons Routinely use this to support and maintain primary murine cholinergic neurons in culture. Excellent product. 에서: Bernadeta | 날짜: 2020-08-26 × Supports Growth of Cholinergic Neurons Routinely use this to support and maintain primary murine cholinergic neurons in culture. Excellent product. 에서: Bernadeta | 날짜: 2020-08-26 Close Differentiation and support of SH-SY5Y cells I have been using this product for over 3 years now to support and differentiate SH-SY5Y cells in culture. It is an excellent product that many people in my lab use. It always works well and is reliable. 에서: Crystal | 날짜: 2020-08-29 × Differentiation and support of SH-SY5Y cells I have been using this product for over 3 years now to support and differentiate SH-SY5Y cells in culture. It is an excellent product that many people in my lab use. It always works well and is reliable. 에서: Crystal | 날짜: 2020-08-29 Close Works great! Used this product for intravitreal injections in the mouse eye and it worked as anticipated. Very pleased and will continue to purchase for future experiments. 에서: Rebecca | 날짜: 2021-08-03 × Works great! Used this product for intravitreal injections in the mouse eye and it worked as anticipated. Very pleased and will continue to purchase for future experiments. 에서: Rebecca | 날짜: 2021-08-03 Close Supports Growth of Motor Neurons I use this product for supporting the maturation of MNs in vitro, it works well. 에서: meimei | 날짜: 2021-08-04 × Supports Growth of Motor Neurons I use this product for supporting the maturation of MNs in vitro, it works well. 에서: meimei | 날짜: 2021-08-04 Close Cortical Neuron Differentiation Very consistent for stem cell culturing 에서: Danielle | 날짜: 2021-08-24 × Cortical Neuron Differentiation Very consistent for stem cell culturing 에서: Danielle | 날짜: 2021-08-24 Close Great recombinant protein This is a very good recombinant protein to elicit TrkB signaling in cultured neurons at 50 ng/ml concentration or support differentiation of mouse ESC-s to neurons. We haven’t experienced lot to lot variation and delivery is always prompt. We highly recommend. 에서: Epp | 날짜: 2021-08-31 × Great recombinant protein This is a very good recombinant protein to elicit TrkB signaling in cultured neurons at 50 ng/ml concentration or support differentiation of mouse ESC-s to neurons. We haven’t experienced lot to lot variation and delivery is always prompt. We highly recommend. 에서: Epp | 날짜: 2021-08-31 Close
