Recombinant Murine BCA-1/BLC (CXCL13)

Recombinant Murine BCA-1/BLC (CXCL13)

제품 상세

카다로그 번호 250-24

제품 설명

BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor, CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes, and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand

AA Sequence: ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract murine B cells using a concentration of 10.0-100.0 ng/ml.

Cross Reactivity:

human , mouse, N/A

Research Interest

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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21 Jan 2002

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Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response.

Immunity; 23(5) pg527-38

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16286020
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The Journal of Experimental Medicine; 203(11) pg2541-50

30 Oct 2006

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15 Jun 2007

17548624
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Bahar, M W

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS Pathogens; 4(1) pge5

0 Jan 2008

18208323
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Sakthivel, S K

CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

Journal of Immune Based Therapies and Vaccines; 6 pg6

28 Oct 2008

18957084
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Guo, F

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

Blood; 114(14) pg2909-16

1 Oct 2009

19671922
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Al-Shami, A

The adaptor protein Sh2d3c is critical for marginal zone B cell development and function.

Journal of immunology (Baltimore, Md. : 1950); 185(1) pg327-34

1 Jul 2010

20505138
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Jang, I K

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.

Proceedings of the National Academy of Sciences of the United States of America; 108(19) pg7926-31

10 May 2011

21508326
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Kobayashi, M

Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] Î³-irradiation.

Journal of immunology (Baltimore, Md. : 1950); 189(1) pg296-303

1 Jul 2012

22664870
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Zhang, H

Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice.

Journal of immunology (Baltimore, Md. : 1950); 189(3) pg1340-8

1 Aug 2012

22753935
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Zhang, F

Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.

Journal of immunology (Baltimore, Md. : 1950); 190(3) pg1017-25

1 Feb 2013

23267022
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Saez de Guinoa, J

Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse.

Journal of immunology (Baltimore, Md. : 1950); 191(5) pg2742-51

1 Sep 2013

23872053
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Barrio, L

TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases.

Journal of immunology (Baltimore, Md. : 1950); 191(7) pg3867-75

1 Oct 2013

23997213
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Al-Shami, A

Integrin-Î± FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

Journal of immunology (Baltimore, Md. : 1950); 191(7) pg3789-98

1 Oct 2013

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Elgueta, R

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

Journal of immunology (Baltimore, Md. : 1950); 194(2) pg505-13

15 Jan 2015

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Rubtsov, A V

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs.

Journal of immunology (Baltimore, Md. : 1950); 195(1) pg71-9

1 Jul 2015

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Jiang, B

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.

The Journal of Clinical Investigation; 126(2) pg745-61

0 Feb 2016

26752644
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Kusuyama, J

CXCL3 positively regulates adipogenic differentiation.

Journal of Lipid Research; 57(10) pg1806-1820

0 Oct 2016

27512010
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Wu, X

CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain.

Scientific Reports; 6 pg34836

6 Oct 2016

27708397
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Singh, K

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific Reports; 7(1) pg4267

27 Jun 2017

28655871
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Kara, E E

Atypical chemokine receptor 4 shapes activated B cell fate.

The Journal of Experimental Medicine; 215(3) pg801-813

5 Mar 2018

29386231
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Shi, J

PD-1 Controls Follicular T Helper Cell Positioning and Function.

Immunity; 49(2) pg264-274.e4

21 Aug 2018

30076099
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Sáez de Guinoa, J

CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.

Blood; 118(6) pg1560-9

11 Aug 2011

21659539
Show Usages

Sáez de Guinoa, J

CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.

Blood; 118(6) pg1560-9

11 Aug 2011

21659539
Show Usages