Recombinant Murine IL-17A

제품 상세

카다로그 번호 210-17

제품 설명

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Murine IL-17A is a 30.0 kDa, disulfide-linked homodimer of two 133 amino acid, polypeptide chains.

Source: E.coli

Synonyms: IL-17, CTLA-8

AA Sequence (monomer): AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-6 production by NIH 3T3 cells.

Calculated Molecular Weight: 30 kDa

Accession Number: Q62386

Gene ID: 16171

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Mouse, Rat