Recombinant Murine sRANK Ligand (E.coli derived) 1 리뷰Submit a Review 제품 상세 카다로그 번호 315-11 제품 설명 RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANKL is a 19.4 kDa polypeptide comprising the TNF-homologous region of RANKL (174 amino acid residues). Source: E.coli Synonyms: soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor) AA Sequence: PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells. Calculated Molecular Weight: 19.4 kDa Accession Number: O35235 Gene ID: 21943 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Cow + Mouse, Human, Mouse, Rat References PubMed SDS CoA 검색 Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Bone, Skeletal, Cartilage Cancer Diabetes/Weight Regulation Immune System TNF Superfamily product.subtitle.recentcitations 제 1 저자 Chen, Y 주제 miR-486-5p Attenuates Steroid-Induced Adipogenesis and Osteonecrosis of the Femoral Head Via TBX2/P21 Axis. 인용 Stem cells (Dayton, Ohio); 41(7) pg711-723 PubMed ID 37210668 제 1 저자 Huang, M 주제 miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway. 인용 The Journal of Biological Chemistry; 298(7) pg102116 PubMed ID 35691339 제 1 저자 Neto, E 주제 Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition. 인용 Advanced Healthcare Materials; 11(11) pge2102305 PubMed ID 35158409 product.subtitle.productreviews 기존 리뷰 RANKL for Osteoclast Induction Works very well! Along with m-csf, makes mighty fine osteoclasts! Is true to expiration as stated in TDS as well. 에서: Amy | 날짜: 2020-08-26 × RANKL for Osteoclast Induction Works very well! Along with m-csf, makes mighty fine osteoclasts! Is true to expiration as stated in TDS as well. 에서: Amy | 날짜: 2020-08-26 Close