Recombinant Human Amphiregulin 0 ReviewsSubmit a Review Product Details Catalog Number: 100-55B Description: Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues. Source: E.coli Synonyms: AR, AREG, Colorectum cell-derived growth factor (CRDGF) AA Sequence: SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 11.3 kDa Accession Number: P15514 Gene ID: 374 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Cell Culture Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Hara, T Title Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Citation Cancer Cell; 39(6) pg779-792.e11 PubMed ID 34087162 First Author Ghosh, S Title PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR. Citation Cell Reports; 35(8) pg109181 PubMed ID 34038737 First Author Lindzen, M Title Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53 Citation Oncogene; 40(21) pg3665-3679 PubMed ID 33941851
