Animal-Free Cytokines

Animal-Free Recombinant Human BAFF

Product Details

Catalog Number: AF-310-13
Description:

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZTNF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.

Cross Reactivity:
Human, Mouse
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.