Recombinant Human FGF-acidic 0 ReviewsSubmit a Review Product Details Catalog Number: 100-17A Description: FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant Human FGF-acidic is a 16.8 kDa protein consisting of 141 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta AA Sequence: MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.5 ng/ml in the presence of 10 µg/ml heparin, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 16.8 kDa Accession Number: P05230 Gene ID: 2246 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Cow, Hagfish, Hamster, Human, Leech, Mouse, Pig, Rat, Shark, Squid References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Cell Culture FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Haensel, D Title LY6D marks pre-existing resistant basosquamous tumor subpopulations. Citation Nature Communications; 13(1) pg7520 PubMed ID 36473848 First Author Hu, H Title Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. Citation Cancer Cell; 39(11) pg1531-1547.e10 PubMed ID 34624218 First Author Yu, K Title Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses. Citation Cell Reports; 35(12) pg109273 PubMed ID 34161766
