Growth Factors & Cytokines

Recombinant Human IFN-α

Product Details

Catalog Number: 300-02AA
Description:

Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid stable molecule that signals through IFNα/βR, which is also used by IFN-β. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-α contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFN-α is a 19.2 kDa protein containing 165 amino acid residues.

Note: Due to patent, this product is not available to all customers. Please contact your local sales office for further information.

Source: E.coli

Synonyms: Leukocyte interferon, B cell interferon, Type I interferon

AA Sequence: CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The specific activity as determined in a viral resistance assay was found to be ≥ 1.8 x 108 units/mg.

Cross Reactivity:
Human

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.