Growth Factors & Cytokines

Recombinant Human IL-16 (129 a.a.)

Product Details

Catalog Number: 200-16
Description:

IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells, CD4+ monocytes, and eosinophils.  Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer.  However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity.  IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells.  Human and murine IL-16 show significant cross-species reactivity.  Recombinant Human IL-16 is a 13.3 kDa protein consisting of 129 amino acid residues.

Source: E.coli

Synonyms: LCF (Lymphocyte Chemoattractant Factor)

AA Sequence: PDLNSSTDSA ASASAASDVS VESTAEATVC TVTLEKMSAG LGFSLEGGKG SLHGDKPLTI NRIFKGAASE QSETVQPGDE ILQLGGTAMQ GLTRFEAWNI IKALPDGPVT IVIRRKSLQS KETTAAGDS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 1.0-100.0 ng/ml.

Cross Reactivity:
Human, Human + Mouse, Leech, Mouse
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.