Animal-Free Cytokines

Animal-Free Recombinant Human IL-1RA

Product Details

Catalog Number: AF-200-01RA
Description:

Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein.  It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors.  IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.  Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.  Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN

AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell.  The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.

Cross Reactivity:
Frog, Human, Mouse, Rat
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.