Growth Factors & Cytokines

Recombinant Human IL-36β (IL-1F8)

Product Details

Catalog Number: 200-36B
Description:

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-κB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

Source: E.coli

Synonyms: Interleukin-36β, IL-1F8 , IL-1H2, IL-1 eta

AA Sequence: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-8 production by human PBMCs.

Cross Reactivity:
Human
Research Interest

Country Of Origin: USA

Not for human use.