Neurotrophins

Recombinant Human Midkine

Product Details

Catalog Number: 450-16
Description:

Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK).  MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development.  MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis.  Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

Source: E.coli

Synonyms: MK, NEGF-2

AA Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.

Cross Reactivity:
Bacteria, Hagfish, Human, Mouse, Pig, Shark, Squid
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.