Other Proteins

Recombinant Human NP-1

Product Details

Catalog Number: 300-42
Description:

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds.  In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells.  NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide.  NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.

Source: E.coli

Synonyms: Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin

AA Sequence: ACYCRIPACI AGERRYGTCI YQGRLWAFCC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.

Cross Reactivity:
Human
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.