The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa, and functions as a gastric-specific tumor suppressor gene. Recombinant Human TFF-1 is a 6.7 kDa monomeric protein consisting of a 60 amino acid polypeptide chain, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Trefoil Factor 1 (TFF1), pS2 protein, HP1.A, Breast Cancer Estrogen-Inducible protein (BCEI), PNR2
EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract human MCF-7 cells using a concentration 5-10 μg/ml.