Animal-Free Recombinant Human/Murine/Rat BDNF 0 ReviewsSubmit a Review Product Details Catalog Number: AF-450-02 Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Brain Derived Neurotrophic Factor, Abrineurin AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 27 kDa Accession Number: P23560 Gene ID: 627 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Chicken, Frog, Guinea Pig, Hamster, Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Neurobiology Stem Cells & Differentiation Recent Citations First Author Özcan, A Title Programmable RNA targeting with the single-protein CRISPR effector Cas7-11 Citation Nature; 597(7878) pg720-725 PubMed ID 34489594 First Author Hong, S P Title Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Citation Nature Communications; 11(1) pg4102 PubMed ID 32796823 First Author Zhang, W Title Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation. Citation Stem Cell Reports; 15(1) pg185-197 PubMed ID 32502463
