Animal-Free Cytokines

Animal-Free Recombinant Murine IL-6

Product Details

Catalog Number: AF-216-16
Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.  Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions.  It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism.  IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130.  Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.  Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse 7TD1 cells. The expected ED50 is ≤ 0.02 ng/ml, corresponding to a specific activity of ≥ 5 x 107 units/mg.

Cross Reactivity:
Human + Mouse, Monkey, Mouse, Mouse + Bacteria, Rat
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.