Animal-Free Recombinant Murine IL-6 0 ReviewsSubmit a Review Product Details Catalog Number: AF-216-16 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 21.7 kDa Accession Number: P08505 Gene ID: 16193 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human + Mouse, Monkey, Mouse, Mouse + Bacteria, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation Recent Citations First Author Duan, H Title CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(13) pge2103719 PubMed ID 35258174 First Author Fiancette, R Title Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity Citation Nature Immunology; 22(10) pg1245-1255 PubMed ID 34556884 First Author Sapra, L Title Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice. Citation Scientific Reports; 11(1) pg1807 PubMed ID 33469043
