Animal-Free Cytokines

Animal-Free Recombinant Murine VEGF 165

Product Details

Catalog Number: AF-450-32
Description:

VEGF is a potent growth and angiogenic cytokine.  It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.  Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis.  Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes.  VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.  Recombinant Murine VEGF165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor165, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A

AA Sequence (monomer): MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml.

Cross Reactivity:
Mouse, Salamander
Research Interest

Country Of Origin: USA

Not for human use.