Animal-Free Recombinant Murine VEGF165 0 ReviewsSubmit a Review Product Details Catalog Number: AF-450-32 Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Murine VEGF165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Vascular Endothelial Growth Factor165, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A AA Sequence (monomer): MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml. Calculated Molecular Weight: 39 kDa Accession Number: Q00731 Gene ID: 22339 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Mouse, Salamander References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Stem Cells & Differentiation Recent Citations First Author Hou, S Title Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses Citation Cell Research; 30(5) pg376-392 PubMed ID 32203131 First Author Chen, X Title The Axolotl Fibula as a Model for the Induction of Regeneration across Large Segment Defects in Long Bones of the Extremities. Citation PLoS ONE; 10(6) pge0130819 PubMed ID 26098852 First Author Christoffersson, G Title VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Citation Blood; 120(23) pg4653-62 PubMed ID 22966168
