Research Areas

TNF Superfamily

Recognized for their involvement in the regulation of a broad spectrum of biological processes, such as cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation, members of the Tumor Necrosis Factor (TNF) Superfamily were originally identified as necrosis-inducing, anti-tumor cytokines for their ability to cause cell death in sarcomas and other cancerous cells.  The members of the TNF Superfamily are responsible for the regulation of cellular differentiation, survival and death through the activation of multiple signal transduction pathways by ligand mediated trimerization and the resulting recruitment of several intracellular adaptors.  Although normal levels of activity can be pivotal in terms of cellular growth and regeneration, as well as regulated events of apoptosis and inflammatory response, accumulating evidence indicates that the uncontrolled synthesis of TNF Superfamily proteins can be linked to a number of human diseases and disorders of chronic inflammation, as well as autoimmune diseases, insulin resistance, and cancer.  Consequently, a great deal of interest surrounds the understanding of those pathways associated with the activity of TNF Superfamily cytokines and the development of therapeutic methods of inhibition and regulation of TNF activity, release, translation and transcription.

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80.00 USD 5µg
195.00 USD 20µg
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80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
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5,200.00 USD 1mg
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Size

80.00 USD 5µg
195.00 USD 20µg
510.00 USD 50µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
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Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
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80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
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Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
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80.00 USD 5µg
195.00 USD 20µg
780.00 USD 100µg
1,365.00 USD 250µg
2,340.00 USD 500µg
3,900.00 USD 1mg
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80.00 USD 2µg
195.00 USD 10µg
624.00 USD 50µg
1,040.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
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80.00 USD 20µg
195.00 USD 100µg
385.00 USD 250µg
660.00 USD 500µg
1,100.00 USD 1mg
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Size

80.00 USD 5µg
195.00 USD 20µg
360.00 USD 50µg
600.00 USD 100µg
1,050.00 USD 250µg
1,800.00 USD 500µg
3,000.00 USD 1mg
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Size

80.00 USD 5µg
195.00 USD 20µg
600.00 USD 100µg
1,050.00 USD 250µg
1,800.00 USD 500µg
3,000.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
Contact Us

Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 5µg
195.00 USD 20µg
360.00 USD 50µg
600.00 USD 100µg
1,050.00 USD 250µg
1,800.00 USD 500µg
3,000.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 5µg
195.00 USD 25µg
600.00 USD 100µg
1,050.00 USD 250µg
1,800.00 USD 500µg
3,000.00 USD 1mg
Looking for a custom size?
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Size

80.00 USD 5µg
195.00 USD 25µg
600.00 USD 100µg
1,050.00 USD 250µg
1,800.00 USD 500µg
3,000.00 USD 1mg
Looking for a custom size?
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