Recombinant Human ApoE2 0 评论Submit a Review 产品详情 产品编号: 350-12 产品描述: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant Human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues. Source: E.coli Synonyms: Apolipoprotein E2 AA Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKCL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 34.3 kDa Accession Number: P02649 Gene ID: 348 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 免疫系统 炎症 product.subtitle.recentcitations 第一作者 Chikazawa, M 标题 Glycolaldehyde is an endogenous source of lysine N-pyrrolation. 文献引用 The Journal of Biological Chemistry; 295(22) pg7697-7709 PubMed Id 32332094 第一作者 Ramms, B 标题 ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. 文献引用 Journal of Lipid Research; 60(8) pg1379-1395 PubMed Id 31092690 第一作者 Tiaden, A N 标题 Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation. 文献引用 Stem cells (Dayton, Ohio); 34(6) pg1601-14 PubMed Id 26864869