Recombinant Human Artemin 0 评论Submit a Review 产品详情 产品编号： 450-17 产品描述： Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, artemin, neurturin and persephin. These proteins belong to the cysteine knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, persephin and neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRα (α1-α4) receptors. Artemin prefers the receptor GFRα3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia, such as sympathetic, neural crest and placodally-derived sensory neurons, and dopaminergic midbrain neurons. The functional human artemin ligand is a disulfide-linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine-knot configuration. Recombinant Human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits. Source: E.coli Synonyms: ART, ARTN, Enovin, Neublastin AA Sequence (monomer): AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to promote survival and neurite outgrowth and dorsal root ganglion neurons. Calculated Molecular Weight: 24.2 kDa Accession Number: Q5T4W7 Gene ID: 9048 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞培养 免疫系统 神经生物学 干细胞&分化 TGF-β超家族 product.subtitle.recentcitations 第一作者 Hedstrom, K L 标题 Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling. 文献引用 Proceedings of the National Academy of Sciences of the United States of America; 111(6) pg2325-30 PubMed Id 24449858 第一作者 Banerjee, A 标题 ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling. 文献引用 PLoS ONE; 7(11) pge50098 PubMed Id 23185544 第一作者 Schmutzler, B S 标题 Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization. 文献引用 Molecular Pain; 7 pg22 PubMed Id 21450093
