Recombinant Human BD-3 0 评论Submit a Review 产品详情 产品编号: 300-52 产品描述: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues. Source: E.coli Synonyms: Beta-Defensin 3, DEFB3, DEFB103A AA Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli. Calculated Molecular Weight: 5.1 kDa Accession Number: P81534 Gene ID: 55894 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse, Virus References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 化学趋化 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 Ting, D S 标题 Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis 文献引用 Scientific Reports; 11(1) pg18304 PubMed Id 34526600 第一作者 Abou Alaiwa, M H 标题 pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37. 文献引用 Proceedings of the National Academy of Sciences of the United States of America; 111(52) pg18703-8 PubMed Id 25512526 第一作者 Dietrich, D E 标题 Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica). 文献引用 Peptides; 53 pg265-9 PubMed Id 24495736