Recombinant Human BMP-6 0 评论Submit a Review 产品详情 产品编号: 120-06 产品描述: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity, and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines, however, its function in promoting breast cancer development is unknown. The mature and functional form of BMP-6 is a homodimer of two identical 139 amino acid polypeptide chains linked by a single disulfide bond. Each monomer is expressed as the C-terminal part of a precursor polypeptide, which contains a 20 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor. Source: HEK293 cells Synonyms: Bone Morphogenetic Protein-6, VGR, VG-1-related protein AA Sequence (monomer): VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml. Calculated Molecular Weight: 26.2 kDa Accession Number: P22004 Gene ID: 654 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Human + Mouse, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 骨/骨骼系统/软骨 细胞培养 免疫系统 神经生物学 干细胞&分化 TGF-β超家族 product.subtitle.recentcitations 第一作者 Kondo, M 标题 Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment 文献引用 NPJ Regenerative Medicine; 6(1) pg65 PubMed Id 34654830 第一作者 Colucci, S 标题 Liver Sinusoidal Endothelial Cells Suppress Bone Morphogenetic Protein 2 Production in Response to TGFβ Pathway Activation. 文献引用 Hepatology (Baltimore, Md.); 74(4) pg2186-2200 PubMed Id 33982327 第一作者 Armandari, I 标题 CREB signaling activity correlates with differentiation and survival in medulloblastoma 文献引用 Scientific Reports; 11(1) pg16077 PubMed Id 34373489