Recombinant Human CYR61 0 评论Submit a Review 产品详情 产品编号： 120-25 产品描述： CYR61 is a member of the CCN family of secreted cysteine-rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant Human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK). Source: E.coli Synonyms: Cellular Communication Network Factor 1 (CCN1), GIG1 protein, Cysteine-rich angiogenic inducer 61, IGF-BP10 AA Sequence: TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml. Calculated Molecular Weight: 39.4 kDa Accession Number: O00622 Gene ID: 3491 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Chicken, Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 癌症 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 Morrell, E D 标题 Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity. 文献引用 American Journal of Physiology. Lung Cellular and Molecular Physiology; 319(5) pgL825-L832 PubMed Id 32936024 第一作者 Zhou, Y 标题 The CCN1 (CYR61) protein promotes skin growth by enhancing epithelial-mesenchymal transition during skin expansion. 文献引用 Journal of Cellular and Molecular Medicine; 24(2) pg1460-1473 PubMed Id 31828970 第一作者 Schlage, P 标题 Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions. 文献引用 Molecular & cellular proteomics : MCP; 14(12) pg3234-46 PubMed Id 26475864
