Recombinant Human DKK-1 0 评论Submit a Review 产品详情 产品编号: 120-30 产品描述: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Mature human DKK-1 expressed in HEK293 cells is a 35-40 kDa glycoprotein containing 235 amino acid residues. The calculated molecular weight of Recombinant Human DKK-1 expressed in HEK293 cells is 25.8 kDa. Source: HEK293 cells Synonyms: Dickkopf-related protein-1, Dickkopf-1, SK AA Sequence: TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit mWnt3a-induced TCF/LEF-luciferase activity in reporter HEK293 cells. Calculated Molecular Weight: 25.8 kDa Accession Number: O94907 Gene ID: 22943 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids 骨/骨骼系统/软骨 癌症 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Hu, D 标题 Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease 文献引用 Nature Communications; 12(1) pg5305 PubMed Id 34489447 第一作者 Scheibner, K 标题 Epithelial cell plasticity drives endoderm formation during gastrulation 文献引用 Nature Cell Biology; 23(7) pg692-703 PubMed Id 34168324 第一作者 Yang, J M 标题 Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats 文献引用 Experimental and Molecular Medicine; 53(4) pg631-642 PubMed Id 33828232