Recombinant Human EPO 0 评论Submit a Review 产品详情 产品编号: 100-64 产品描述: Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions. Source: CHO cells Synonyms: Erythropoietin, Epoetin AA Sequence: APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.4 kDa Accession Number: P01588 Gene ID: 2056 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Virus, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 免疫系统 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Chen, W 标题 Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. 文献引用 Communications Biology; 6(1) pg393 PubMed Id 37041280 第一作者 Atkins, M H 标题 Modeling human yolk sac hematopoiesis with pluripotent stem cells. 文献引用 The Journal of Experimental Medicine; 219(3) PubMed Id 34928315 第一作者 Ito, K 标题 Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics. 文献引用 Communications Biology; 5(1) pg56 PubMed Id 35031676